Loading…
The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome
Objective: To modulate the inflammatory response in respiratory distress syndrome (ARDS) with selenium. Background: Selenium replenishes the glutathione peroxidase proteins that are the first line of defense for an oxidative injury to the lungs. Methods: Forty patients with ARDS were randomized into...
Saved in:
| Published in: | Immunological investigations 2019-02, Vol.48 (2), p.147-159 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c366t-fbe0207591b207da32f4f43e42add1dec5564e290257c0161d14361751356213 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c366t-fbe0207591b207da32f4f43e42add1dec5564e290257c0161d14361751356213 |
| container_end_page | 159 |
| container_issue | 2 |
| container_start_page | 147 |
| container_title | Immunological investigations |
| container_volume | 48 |
| creator | Mahmoodpoor, Ata Hamishehkar, Hadi Shadvar, Kamran Ostadi, Zohreh Sanaie, Sarvin Saghaleini, Seied Hadi Nader, Nader D. |
| description | Objective: To modulate the inflammatory response in respiratory distress syndrome (ARDS) with selenium.
Background: Selenium replenishes the glutathione peroxidase proteins that are the first line of defense for an oxidative injury to the lungs.
Methods: Forty patients with ARDS were randomized into two groups: the SEL
+
group being administered sodium selenite and the SEL
-
group receiving normal saline for 10 days. Blood samples were taken on Day-0, DAY-7, and Day-14 for assessment of IL-1 beta, IL-6, C-reactive protein, GPx-3, and selenium. Ferric reducing antioxidant power (FRAP) was measured in the bronchial wash fluids. Pearson correlation and repeated measure analysis were performed to examine the effects of selenium on the inflammatory markers.
Results: Sodium selenite replenished selenium levels in the SEL
+
group. Selenium concentrations were linearly correlated to serum concentrations of GPx3 (R value: 0.631; P |
| doi_str_mv | 10.1080/08820139.2018.1496098 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_08820139_2018_1496098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2070239515</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-fbe0207591b207da32f4f43e42add1dec5564e290257c0161d14361751356213</originalsourceid><addsrcrecordid>eNp9kMFuEzEQhi0EoiHwCCAfuWzwrNeb3RtVWiBSpSKSu-Wsx6qR1w62t2V5ehwl5cjFY2m-f0bzEfIe2ApYxz6xrqsZ8H5V3m4FTd-yvntBFiB4XTUc4CVZnJjqBF2RNyn9ZIxx0favyRUvX4A1LMif_QPSW2NwyDQYuvU5qkf0YUp0hw69nUYaPL3_bbXK9hHpLkdMiVpPN9FmOyjnZrp1jn4vffQ50SebH-j1MGWkPzAdbVQ5xJne2HSO7mavYxjxLXlllEv47lKXZP_ldr_5Vt3df91uru-qgbdtrswBWc3WoodDKVrx2jSm4djUSmvQOAjRNlj3rBbrgUELGhrewlpAObYGviQfz2OPMfyaMGU52jSgc8pjOVOWoazmvSjilkSc0SGGlCIaeYx2VHGWwOTJuny2Lk_W5cV6yX24rJgOI-p_qWfNBfh8Bqw3IY7qKUSnZVazC9FE5QebJP__jr8Xi5Fq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2070239515</pqid></control><display><type>article</type><title>The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Mahmoodpoor, Ata ; Hamishehkar, Hadi ; Shadvar, Kamran ; Ostadi, Zohreh ; Sanaie, Sarvin ; Saghaleini, Seied Hadi ; Nader, Nader D.</creator><creatorcontrib>Mahmoodpoor, Ata ; Hamishehkar, Hadi ; Shadvar, Kamran ; Ostadi, Zohreh ; Sanaie, Sarvin ; Saghaleini, Seied Hadi ; Nader, Nader D.</creatorcontrib><description>Objective: To modulate the inflammatory response in respiratory distress syndrome (ARDS) with selenium.
Background: Selenium replenishes the glutathione peroxidase proteins that are the first line of defense for an oxidative injury to the lungs.
Methods: Forty patients with ARDS were randomized into two groups: the SEL
+
group being administered sodium selenite and the SEL
-
group receiving normal saline for 10 days. Blood samples were taken on Day-0, DAY-7, and Day-14 for assessment of IL-1 beta, IL-6, C-reactive protein, GPx-3, and selenium. Ferric reducing antioxidant power (FRAP) was measured in the bronchial wash fluids. Pearson correlation and repeated measure analysis were performed to examine the effects of selenium on the inflammatory markers.
Results: Sodium selenite replenished selenium levels in the SEL
+
group. Selenium concentrations were linearly correlated to serum concentrations of GPx3 (R value: 0.631; P < 0.001), and FRAP (R value: −0.785; P < 0.001). Serum concentrations of both IL 1-beta (R value: −0.624; P < 0.001) and IL-6 (R value: −0.642; P < 0.001) were inversely correlated to the serum concentrations of selenium. There was a meaningful difference between two groups in airway resistance and pulmonary compliance changes (P values 0.008 and 0.028, respectively).
Conclusion: Selenium restored the antioxidant capacity of the lungs, moderated the inflammatory responses, and meaningfully improved the respiratory mechanics. Despite these changes, it had no effect on the overall survival, the duration of mechanical ventilation, and ICU stay. Selenium can be used safely; however, more trials are essential to examine its clinical effectiveness.</description><identifier>ISSN: 0882-0139</identifier><identifier>EISSN: 1532-4311</identifier><identifier>DOI: 10.1080/08820139.2018.1496098</identifier><identifier>PMID: 30001171</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Administration, Intravenous ; Aged ; Antioxidant activity ; Antioxidants - administration & dosage ; Biomarkers ; Critical Illness ; Female ; Humans ; Inflammatory response ; Male ; Middle Aged ; Oxidation-Reduction - drug effects ; Oxidative Stress - drug effects ; Oxygen radicals ; Pilots ; Respiratory distress ; Respiratory Distress Syndrome, Adult - diagnosis ; Respiratory Distress Syndrome, Adult - drug therapy ; Respiratory Distress Syndrome, Adult - etiology ; Respiratory Distress Syndrome, Adult - metabolism ; Respiratory Function Tests ; Selenium - administration & dosage ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>Immunological investigations, 2019-02, Vol.48 (2), p.147-159</ispartof><rights>2018 Taylor & Francis 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-fbe0207591b207da32f4f43e42add1dec5564e290257c0161d14361751356213</citedby><cites>FETCH-LOGICAL-c366t-fbe0207591b207da32f4f43e42add1dec5564e290257c0161d14361751356213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30001171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahmoodpoor, Ata</creatorcontrib><creatorcontrib>Hamishehkar, Hadi</creatorcontrib><creatorcontrib>Shadvar, Kamran</creatorcontrib><creatorcontrib>Ostadi, Zohreh</creatorcontrib><creatorcontrib>Sanaie, Sarvin</creatorcontrib><creatorcontrib>Saghaleini, Seied Hadi</creatorcontrib><creatorcontrib>Nader, Nader D.</creatorcontrib><title>The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome</title><title>Immunological investigations</title><addtitle>Immunol Invest</addtitle><description>Objective: To modulate the inflammatory response in respiratory distress syndrome (ARDS) with selenium.
Background: Selenium replenishes the glutathione peroxidase proteins that are the first line of defense for an oxidative injury to the lungs.
Methods: Forty patients with ARDS were randomized into two groups: the SEL
+
group being administered sodium selenite and the SEL
-
group receiving normal saline for 10 days. Blood samples were taken on Day-0, DAY-7, and Day-14 for assessment of IL-1 beta, IL-6, C-reactive protein, GPx-3, and selenium. Ferric reducing antioxidant power (FRAP) was measured in the bronchial wash fluids. Pearson correlation and repeated measure analysis were performed to examine the effects of selenium on the inflammatory markers.
Results: Sodium selenite replenished selenium levels in the SEL
+
group. Selenium concentrations were linearly correlated to serum concentrations of GPx3 (R value: 0.631; P < 0.001), and FRAP (R value: −0.785; P < 0.001). Serum concentrations of both IL 1-beta (R value: −0.624; P < 0.001) and IL-6 (R value: −0.642; P < 0.001) were inversely correlated to the serum concentrations of selenium. There was a meaningful difference between two groups in airway resistance and pulmonary compliance changes (P values 0.008 and 0.028, respectively).
Conclusion: Selenium restored the antioxidant capacity of the lungs, moderated the inflammatory responses, and meaningfully improved the respiratory mechanics. Despite these changes, it had no effect on the overall survival, the duration of mechanical ventilation, and ICU stay. Selenium can be used safely; however, more trials are essential to examine its clinical effectiveness.</description><subject>Administration, Intravenous</subject><subject>Aged</subject><subject>Antioxidant activity</subject><subject>Antioxidants - administration & dosage</subject><subject>Biomarkers</subject><subject>Critical Illness</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory response</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxygen radicals</subject><subject>Pilots</subject><subject>Respiratory distress</subject><subject>Respiratory Distress Syndrome, Adult - diagnosis</subject><subject>Respiratory Distress Syndrome, Adult - drug therapy</subject><subject>Respiratory Distress Syndrome, Adult - etiology</subject><subject>Respiratory Distress Syndrome, Adult - metabolism</subject><subject>Respiratory Function Tests</subject><subject>Selenium - administration & dosage</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>0882-0139</issn><issn>1532-4311</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kMFuEzEQhi0EoiHwCCAfuWzwrNeb3RtVWiBSpSKSu-Wsx6qR1w62t2V5ehwl5cjFY2m-f0bzEfIe2ApYxz6xrqsZ8H5V3m4FTd-yvntBFiB4XTUc4CVZnJjqBF2RNyn9ZIxx0favyRUvX4A1LMif_QPSW2NwyDQYuvU5qkf0YUp0hw69nUYaPL3_bbXK9hHpLkdMiVpPN9FmOyjnZrp1jn4vffQ50SebH-j1MGWkPzAdbVQ5xJne2HSO7mavYxjxLXlllEv47lKXZP_ldr_5Vt3df91uru-qgbdtrswBWc3WoodDKVrx2jSm4djUSmvQOAjRNlj3rBbrgUELGhrewlpAObYGviQfz2OPMfyaMGU52jSgc8pjOVOWoazmvSjilkSc0SGGlCIaeYx2VHGWwOTJuny2Lk_W5cV6yX24rJgOI-p_qWfNBfh8Bqw3IY7qKUSnZVazC9FE5QebJP__jr8Xi5Fq</recordid><startdate>20190217</startdate><enddate>20190217</enddate><creator>Mahmoodpoor, Ata</creator><creator>Hamishehkar, Hadi</creator><creator>Shadvar, Kamran</creator><creator>Ostadi, Zohreh</creator><creator>Sanaie, Sarvin</creator><creator>Saghaleini, Seied Hadi</creator><creator>Nader, Nader D.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190217</creationdate><title>The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome</title><author>Mahmoodpoor, Ata ; Hamishehkar, Hadi ; Shadvar, Kamran ; Ostadi, Zohreh ; Sanaie, Sarvin ; Saghaleini, Seied Hadi ; Nader, Nader D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-fbe0207591b207da32f4f43e42add1dec5564e290257c0161d14361751356213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Administration, Intravenous</topic><topic>Aged</topic><topic>Antioxidant activity</topic><topic>Antioxidants - administration & dosage</topic><topic>Biomarkers</topic><topic>Critical Illness</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory response</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxygen radicals</topic><topic>Pilots</topic><topic>Respiratory distress</topic><topic>Respiratory Distress Syndrome, Adult - diagnosis</topic><topic>Respiratory Distress Syndrome, Adult - drug therapy</topic><topic>Respiratory Distress Syndrome, Adult - etiology</topic><topic>Respiratory Distress Syndrome, Adult - metabolism</topic><topic>Respiratory Function Tests</topic><topic>Selenium - administration & dosage</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahmoodpoor, Ata</creatorcontrib><creatorcontrib>Hamishehkar, Hadi</creatorcontrib><creatorcontrib>Shadvar, Kamran</creatorcontrib><creatorcontrib>Ostadi, Zohreh</creatorcontrib><creatorcontrib>Sanaie, Sarvin</creatorcontrib><creatorcontrib>Saghaleini, Seied Hadi</creatorcontrib><creatorcontrib>Nader, Nader D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunological investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmoodpoor, Ata</au><au>Hamishehkar, Hadi</au><au>Shadvar, Kamran</au><au>Ostadi, Zohreh</au><au>Sanaie, Sarvin</au><au>Saghaleini, Seied Hadi</au><au>Nader, Nader D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome</atitle><jtitle>Immunological investigations</jtitle><addtitle>Immunol Invest</addtitle><date>2019-02-17</date><risdate>2019</risdate><volume>48</volume><issue>2</issue><spage>147</spage><epage>159</epage><pages>147-159</pages><issn>0882-0139</issn><eissn>1532-4311</eissn><abstract>Objective: To modulate the inflammatory response in respiratory distress syndrome (ARDS) with selenium.
Background: Selenium replenishes the glutathione peroxidase proteins that are the first line of defense for an oxidative injury to the lungs.
Methods: Forty patients with ARDS were randomized into two groups: the SEL
+
group being administered sodium selenite and the SEL
-
group receiving normal saline for 10 days. Blood samples were taken on Day-0, DAY-7, and Day-14 for assessment of IL-1 beta, IL-6, C-reactive protein, GPx-3, and selenium. Ferric reducing antioxidant power (FRAP) was measured in the bronchial wash fluids. Pearson correlation and repeated measure analysis were performed to examine the effects of selenium on the inflammatory markers.
Results: Sodium selenite replenished selenium levels in the SEL
+
group. Selenium concentrations were linearly correlated to serum concentrations of GPx3 (R value: 0.631; P < 0.001), and FRAP (R value: −0.785; P < 0.001). Serum concentrations of both IL 1-beta (R value: −0.624; P < 0.001) and IL-6 (R value: −0.642; P < 0.001) were inversely correlated to the serum concentrations of selenium. There was a meaningful difference between two groups in airway resistance and pulmonary compliance changes (P values 0.008 and 0.028, respectively).
Conclusion: Selenium restored the antioxidant capacity of the lungs, moderated the inflammatory responses, and meaningfully improved the respiratory mechanics. Despite these changes, it had no effect on the overall survival, the duration of mechanical ventilation, and ICU stay. Selenium can be used safely; however, more trials are essential to examine its clinical effectiveness.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>30001171</pmid><doi>10.1080/08820139.2018.1496098</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0882-0139 |
| ispartof | Immunological investigations, 2019-02, Vol.48 (2), p.147-159 |
| issn | 0882-0139 1532-4311 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_08820139_2018_1496098 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Administration, Intravenous Aged Antioxidant activity Antioxidants - administration & dosage Biomarkers Critical Illness Female Humans Inflammatory response Male Middle Aged Oxidation-Reduction - drug effects Oxidative Stress - drug effects Oxygen radicals Pilots Respiratory distress Respiratory Distress Syndrome, Adult - diagnosis Respiratory Distress Syndrome, Adult - drug therapy Respiratory Distress Syndrome, Adult - etiology Respiratory Distress Syndrome, Adult - metabolism Respiratory Function Tests Selenium - administration & dosage Severity of Illness Index Treatment Outcome |
| title | The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T04%3A03%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Intravenous%20Selenium%20on%20Oxidative%20Stress%20in%20Critically%20Ill%20Patients%20with%20Acute%20Respiratory%20Distress%20Syndrome&rft.jtitle=Immunological%20investigations&rft.au=Mahmoodpoor,%20Ata&rft.date=2019-02-17&rft.volume=48&rft.issue=2&rft.spage=147&rft.epage=159&rft.pages=147-159&rft.issn=0882-0139&rft.eissn=1532-4311&rft_id=info:doi/10.1080/08820139.2018.1496098&rft_dat=%3Cproquest_cross%3E2070239515%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c366t-fbe0207591b207da32f4f43e42add1dec5564e290257c0161d14361751356213%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2070239515&rft_id=info:pmid/30001171&rfr_iscdi=true |