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ANTI-HIV AND -SIV IMMUNITY IN THE VAGINA
Most HIV infections worldwide are transmitted through heterosexual contact. In order to develop vaccination strategies, the basic biology of the immune system in female reproductive tract and the full range of vaginal immune responses that occur during natural HIV infection must be understood. The c...
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| Published in: | International reviews of immunology 2003, Vol.22 (1), p.65-76 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c421t-55603999662b0e84fa7a4a6659e205776e1f00cdd7edeaa7122cc427c676b9f03 |
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| cites | cdi_FETCH-LOGICAL-c421t-55603999662b0e84fa7a4a6659e205776e1f00cdd7edeaa7122cc427c676b9f03 |
| container_end_page | 76 |
| container_issue | 1 |
| container_start_page | 65 |
| container_title | International reviews of immunology |
| container_volume | 22 |
| creator | MILLER, CHRISTOPHER J. LÜ, FABIEN X. |
| description | Most HIV infections worldwide are transmitted through heterosexual contact. In order to develop vaccination strategies, the basic biology of the immune system in female reproductive tract and the full range of vaginal immune responses that occur during natural HIV infection must be understood. The cervicovaginal mucosa contains a complete set of immune cells, including antigen-presenting cells, CD4+ and CD8+ T cells, and B cells. The CVS of HIV-infected women and SIV-infected female rhesus macaques contain variable levels of antiviral antibodies. Some of this variation is due to the effects of female ovarian hormone cycle. IgG antibodies make up the bulk of the antiviral antibody response. However, IgA antibodies are present at lower levels. HIV SIV-specific CD8+ cytotoxic T lymphocytes are present in the cervicovaginal mucosa of infected women and rhesus macaques. A vaccine that can elicit strong antiviral immunity may provide protection for hetorosexual HIV-1 transmission. |
| doi_str_mv | 10.1080/08830180305230 |
| format | article |
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In order to develop vaccination strategies, the basic biology of the immune system in female reproductive tract and the full range of vaginal immune responses that occur during natural HIV infection must be understood. The cervicovaginal mucosa contains a complete set of immune cells, including antigen-presenting cells, CD4+ and CD8+ T cells, and B cells. The CVS of HIV-infected women and SIV-infected female rhesus macaques contain variable levels of antiviral antibodies. Some of this variation is due to the effects of female ovarian hormone cycle. IgG antibodies make up the bulk of the antiviral antibody response. However, IgA antibodies are present at lower levels. HIV SIV-specific CD8+ cytotoxic T lymphocytes are present in the cervicovaginal mucosa of infected women and rhesus macaques. A vaccine that can elicit strong antiviral immunity may provide protection for hetorosexual HIV-1 transmission.</description><identifier>ISSN: 0883-0185</identifier><identifier>EISSN: 1563-5244</identifier><identifier>DOI: 10.1080/08830180305230</identifier><identifier>PMID: 12710504</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>AIDS Vaccines - immunology ; Animals ; Antibodies, Viral - metabolism ; CD8-Positive T-Lymphocytes - immunology ; Female ; Gonadal Steroid Hormones - metabolism ; HIV - immunology ; HIV Antibodies - metabolism ; HIV Infections - immunology ; HIV Infections - prevention & control ; HIV Infections - transmission ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Humans ; Immunity, Mucosal ; Macaca mulatta ; Male ; SAIDS Vaccines - immunology ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - prevention & control ; Simian Immunodeficiency Virus - immunology ; Vagina - immunology ; Vagina - virology</subject><ispartof>International reviews of immunology, 2003, Vol.22 (1), p.65-76</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-55603999662b0e84fa7a4a6659e205776e1f00cdd7edeaa7122cc427c676b9f03</citedby><cites>FETCH-LOGICAL-c421t-55603999662b0e84fa7a4a6659e205776e1f00cdd7edeaa7122cc427c676b9f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12710504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MILLER, CHRISTOPHER J.</creatorcontrib><creatorcontrib>LÜ, FABIEN X.</creatorcontrib><title>ANTI-HIV AND -SIV IMMUNITY IN THE VAGINA</title><title>International reviews of immunology</title><addtitle>Int Rev Immunol</addtitle><description>Most HIV infections worldwide are transmitted through heterosexual contact. In order to develop vaccination strategies, the basic biology of the immune system in female reproductive tract and the full range of vaginal immune responses that occur during natural HIV infection must be understood. The cervicovaginal mucosa contains a complete set of immune cells, including antigen-presenting cells, CD4+ and CD8+ T cells, and B cells. The CVS of HIV-infected women and SIV-infected female rhesus macaques contain variable levels of antiviral antibodies. Some of this variation is due to the effects of female ovarian hormone cycle. IgG antibodies make up the bulk of the antiviral antibody response. However, IgA antibodies are present at lower levels. HIV SIV-specific CD8+ cytotoxic T lymphocytes are present in the cervicovaginal mucosa of infected women and rhesus macaques. A vaccine that can elicit strong antiviral immunity may provide protection for hetorosexual HIV-1 transmission.</description><subject>AIDS Vaccines - immunology</subject><subject>Animals</subject><subject>Antibodies, Viral - metabolism</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Female</subject><subject>Gonadal Steroid Hormones - metabolism</subject><subject>HIV - immunology</subject><subject>HIV Antibodies - metabolism</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Infections - transmission</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunity, Mucosal</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>SAIDS Vaccines - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - prevention & control</subject><subject>Simian Immunodeficiency Virus - immunology</subject><subject>Vagina - immunology</subject><subject>Vagina - virology</subject><issn>0883-0185</issn><issn>1563-5244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkE1rwkAQhpfSUq3ttceSU-kldvY7OQZrNaDpoVHoaVmTDUaisbuR4r9vRKF4kJ5mYJ73ZXgQesTQxxDAKwQBBRwABU4oXKEu5oL6nDB2jbqHo99eeQfdObcCwJSH7BZ1MJEYOLAueomSNPbH8dyLkjfP_2yXeDqdJXH65cWJl46H3jwaxUl0j24KXTnzcJo9NHsfpoOxP_kYxYNo4meM4MbnXAANw1AIsgATsEJLzbQQPDQEuJTC4AIgy3NpcqO1xIRkbVJmQopFWADtoedj79bW3zvjGrUuXWaqSm9MvXNKUsJCwoJ_QQIBI7S10UP9I5jZ2jlrCrW15VrbvcKgDhLVucQ28HRq3i3WJv_DT9ZaIDwC5aao7Vr_1LbKVaP3VW0LqzdZ6RS9WB6cZZdGV80y09aoVb2zm9btpb9-AY9GiRs</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>MILLER, CHRISTOPHER J.</creator><creator>LÜ, FABIEN X.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>ANTI-HIV AND -SIV IMMUNITY IN THE VAGINA</title><author>MILLER, CHRISTOPHER J. ; LÜ, FABIEN X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-55603999662b0e84fa7a4a6659e205776e1f00cdd7edeaa7122cc427c676b9f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>AIDS Vaccines - immunology</topic><topic>Animals</topic><topic>Antibodies, Viral - metabolism</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Female</topic><topic>Gonadal Steroid Hormones - metabolism</topic><topic>HIV - immunology</topic><topic>HIV Antibodies - metabolism</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - prevention & control</topic><topic>HIV Infections - transmission</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunity, Mucosal</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>SAIDS Vaccines - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - prevention & control</topic><topic>Simian Immunodeficiency Virus - immunology</topic><topic>Vagina - immunology</topic><topic>Vagina - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MILLER, CHRISTOPHER J.</creatorcontrib><creatorcontrib>LÜ, FABIEN X.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International reviews of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MILLER, CHRISTOPHER J.</au><au>LÜ, FABIEN X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANTI-HIV AND -SIV IMMUNITY IN THE VAGINA</atitle><jtitle>International reviews of immunology</jtitle><addtitle>Int Rev Immunol</addtitle><date>2003</date><risdate>2003</risdate><volume>22</volume><issue>1</issue><spage>65</spage><epage>76</epage><pages>65-76</pages><issn>0883-0185</issn><eissn>1563-5244</eissn><abstract>Most HIV infections worldwide are transmitted through heterosexual contact. In order to develop vaccination strategies, the basic biology of the immune system in female reproductive tract and the full range of vaginal immune responses that occur during natural HIV infection must be understood. The cervicovaginal mucosa contains a complete set of immune cells, including antigen-presenting cells, CD4+ and CD8+ T cells, and B cells. The CVS of HIV-infected women and SIV-infected female rhesus macaques contain variable levels of antiviral antibodies. Some of this variation is due to the effects of female ovarian hormone cycle. IgG antibodies make up the bulk of the antiviral antibody response. However, IgA antibodies are present at lower levels. HIV SIV-specific CD8+ cytotoxic T lymphocytes are present in the cervicovaginal mucosa of infected women and rhesus macaques. A vaccine that can elicit strong antiviral immunity may provide protection for hetorosexual HIV-1 transmission.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>12710504</pmid><doi>10.1080/08830180305230</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0883-0185 |
| ispartof | International reviews of immunology, 2003, Vol.22 (1), p.65-76 |
| issn | 0883-0185 1563-5244 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_08830180305230 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | AIDS Vaccines - immunology Animals Antibodies, Viral - metabolism CD8-Positive T-Lymphocytes - immunology Female Gonadal Steroid Hormones - metabolism HIV - immunology HIV Antibodies - metabolism HIV Infections - immunology HIV Infections - prevention & control HIV Infections - transmission Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunity, Mucosal Macaca mulatta Male SAIDS Vaccines - immunology Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Immunodeficiency Virus - immunology Vagina - immunology Vagina - virology |
| title | ANTI-HIV AND -SIV IMMUNITY IN THE VAGINA |
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