Diabetes Mellitus Following Cisplatin Treatment

The association between cisplatin treatment and diabetes mellitus was analyzed retrospectively in 219 patients with locally advanced squamous cell head and neck cancer treated in two consecutive trials with cisplatin-based induction chemotherapy. It was found that 11 patients (5%) developed diabetes...

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Bibliographic Details
Published in:Acta oncologica 2003, Vol.42 (1), p.75-78
Main Author: Nan, Daniel N.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Blood Glucose - analysis
Carcinoma, Squamous Cell - drug therapy
Cisplatin - adverse effects
Coma - diagnosis
Diabetes Mellitus - etiology
Drug toxicity and drugs side effects treatment
Female
Head and Neck Neoplasms - drug therapy
Humans
Male
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Retrospective Studies
Citations: Items that cite this one
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Summary:The association between cisplatin treatment and diabetes mellitus was analyzed retrospectively in 219 patients with locally advanced squamous cell head and neck cancer treated in two consecutive trials with cisplatin-based induction chemotherapy. It was found that 11 patients (5%) developed diabetes mellitus during the treatment period, two cases presenting as hyperosmolar coma. The literature contains only sporadic descriptions of cases of hyperosmolar coma related to cisplatin chemotherapy. The present study was initiated owing to a case of hyperosmolar coma observed by us. We suggest that glycemia levels in patients receiving chemotherapy with a cisplatin-based regimen should be monitored regularly.
ISSN:0284-186X
1651-226X
DOI:10.1080/0891060310002276