Levels of BAFF in Serum in Primary Biliary Cirrhosis and Autoimmune Diabetes

Levels of the B-cell activating cytokine BAFF are increased in serum in various autoimmune disease, and particularly Sjögren's syndrome in which there is evident B-lymphocyte proliferation. Studies in two autoimmune disease in which B-cell proliferation is less evident, primary biliary cirrhosi...

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Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2002-12, Vol.35 (8), p.551-553
Main Authors: Mackay, I.R., Groom, J., Mackay, C.R.
Format: Article
Language:English
Subjects:
Autoimmunity
B-Cell Activating Factor
Baff
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - metabolism
Enzyme-Linked Immunosorbent Assay
Humans
Lada
Liver Cirrhosis, Biliary - blood
Liver Cirrhosis, Biliary - metabolism
Membrane Proteins - blood
Primary Biliary Cirrhosis
Sjogren's Syndrome - metabolism
Tumor Necrosis Factor-alpha
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Summary:Levels of the B-cell activating cytokine BAFF are increased in serum in various autoimmune disease, and particularly Sjögren's syndrome in which there is evident B-lymphocyte proliferation. Studies in two autoimmune disease in which B-cell proliferation is less evident, primary biliary cirrhosis (PBC), and adult-onset Type 1 diabetes, showed serum levels of BAFF to be mostly in the normal range. A single raised level among eight sera tested in one patient studied with autoimmune hepatitis (AH) coincided with a relapse of the disease. Increased levels of BAFF in human sera, indexing a potent antigenic drive on B-cell production and survival in some autoimmune diseases, may mark only particular stages in the evolution of such diseases.
ISSN:0891-6934
1607-842X
DOI:10.1080/0891693021000066333