Elevated soluble Tim-3 correlates with disease activity of systemic lupus erythematosus

T cell immunoglobulin and mucin domain-containing molecule-3(Tim-3) has been found to play important roles in systemic lupus erythematosus (SLE), but whether sTim-3 is involved in the development of SLE remains unknown. In this study, we firstly observed an increased expression of plasma sTim-3 in S...

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Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2021-02, Vol.54 (2), p.97-103
Main Authors: Zhao, Di, Li, Chunhao, Yang, Xiao, Yan, Wenjiang, Zhang, Yi
Format: Article
Language:English
Subjects:
disease activity
sTim-3
systemic lupus erythematosus
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Summary:T cell immunoglobulin and mucin domain-containing molecule-3(Tim-3) has been found to play important roles in systemic lupus erythematosus (SLE), but whether sTim-3 is involved in the development of SLE remains unknown. In this study, we firstly observed an increased expression of plasma sTim-3 in SLE patients, especially active SLE patients. The plasma sTim-3 levels were positively correlated with anti-dsDNA, SLEDAI score, ESR, and urine albumin. The plasma sTim-3 levels were negatively correlated with C3 and C4. The area under the ROC curve (AUC) values indicated that the plasma sTim-3 level was significantly discriminative of early active SLE from stable SLE and HC with high sensitivity and specificity. The present results suggest that sTim-3 might serve as a potential biomarker for promising the disease activity of SLE.
ISSN:0891-6934
1607-842X
DOI:10.1080/08916934.2021.1891535