Inhibitors of Snake Venoms and Development of New Therapeutics

Natural inhibitors of snake venoms play a significant role in the ability to neutralize the degradation effects induced by venom toxins. It has been known for many years that animal sera and some plant extracts are competent in neutralizing snake venoms. The purpose of this review is to highlight th...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2008-01, Vol.30 (4), p.647-678
Main Authors: Sánchez, Elda E., Rodríguez-Acosta, Alexis
Format: Article
Language:English
Subjects:
Animals
Antivenins - chemistry
Antivenins - therapeutic use
Endothermic Animals
Hemorrhagic Activity
Humans
Metalloprotease Inhibitors
Plant Extracts
Proteolytic Activity
Snake Bites - drug therapy
Snake Bites - genetics
Snake Bites - immunology
Snake Venom
Snake Venoms - antagonists & inhibitors
Snake Venoms - toxicity
Technology, Pharmaceutical - methods
Technology, Pharmaceutical - trends
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Description
Summary:Natural inhibitors of snake venoms play a significant role in the ability to neutralize the degradation effects induced by venom toxins. It has been known for many years that animal sera and some plant extracts are competent in neutralizing snake venoms. The purpose of this review is to highlight the recent work that has been accomplished with natural inhibitors of snake venoms as well as revisiting the past research including those found in plants. The biomedical value of these natural inhibitors can lead to the development of new therapeutics for an assortment of diseases as well as contributing to efficient antivenoms for the treatment of ophidic accidents.
ISSN:0892-3973
1532-2513
DOI:10.1080/08923970802279019