A New Model of Abdominal Aortic Aneurysm with Gastric Serosa Patch: Surgical Technique and Short-Term Evaluation

• Published in: Journal of investigative surgery 2006-03, Vol.19 (2), p.97-104
• Main Authors: Usón-Gargallo, Jesús, Crisóstomo, Verónica, Loscertales, Beatriz, Sun, Fei, Sánchez-Margallo, Francisco M., Martín-Cancho, Maria F., Maynar, Manuel
• Format: Article
• Language: English
• Subjects: abdominal aortic aneurysm; animal model; Animals; Aortic Aneurysm, Abdominal - diagnostic imaging; Aortic Aneurysm, Abdominal - pathology; Aortic Aneurysm, Abdominal - surgery; Aortic Rupture; Aortography; Cardiovascular Surgical Procedures - methods; Disease Models, Animal; Education, Medical, Graduate; gastric serosa; Serous Membrane - surgery; Stomach - surgery; Swine; Ultrasonography
• ISSN: 0894-1939; 1521-0553
• DOI: 10.1080/08941930600569415

The purpose of this work was to develop an abdominal aortic aneurysm (AAA) model that resembles human aneurysms with potential for further growth, patent collateral vessels, and a predictable tendency to rupture, and that can be used in the development of new endoprostheses and implant training. An infrarenal AAA model was created in five domestic swine using an autologous gastric serosal patch. Pre- and postsurgical digital substraction aortograms (DSA) were obtained to document the appearance and dimensions of the aneurysm. Animals were followed up with DSA and ultrasonography on days 7, 14, 30, 45, 60, and 90 after model creation. Aneurysmal diameters were measured with both techniques in all examinations. On day 90, animals were euthanized, target arteries were harvested, and pathological evaluation was performed. The nonparametric Wilcoxon test was used to assess any differences in measured diameters. All the animals survived the surgical procedure. The aneurysmal diameters increased from 8.14± 2.15 to 13.28± 1.18 mm immediately after surgery (p