Effects of Dexamethasone on Bupivacaine-Induced Peripheral Nerve Injection Injury in the Rat Sciatic Model

• Published in: Journal of investigative surgery 2021-12, Vol.34 (12), p.1339-1347
• Main Authors: Çömez, Mehmet Selim, Borazan, Yakup, Özgür, Tümay, İşler, Cafer Tayer, Cellat, Mustafa, Güvenç, Mehmet, Altuğ, Muhammed Enes
• Format: Article
• Language: English
• Subjects: Anesthetics, Local - adverse effects; Animals; bupivacaine; Bupivacaine - adverse effects; dexamethasone; Dexamethasone - therapeutic use; Injections - adverse effects; Nerve injury; Rats; Sciatic Nerve - injuries
• ISSN: 0894-1939; 1521-0553
• DOI: 10.1080/08941939.2020.1805053

The aim of this study was to investigate the effect of perineural dexamethasone against intraneural bupivacaine. Rats were divided into 9 groups with 6 animals in each group; Group 1 (Intraneural saline 600 µL-2ndday), Group 2 (Intraneural saline 600 µL-7th day), Group 3 (Intraneural saline 600 µL + perineural dexamethasone 0.5 mg/kg-2nd day), Group 4 (Intraneural saline 600 µL + perineural dexamethasone 0.5 mg/kg-7th day), Group 5 (Intraneural bupivacaine 10 mg/kg-2nd day), Group 6 (Intranueral bupivacaine 10 mg/kg-7th day), Group 7 (Intraneural bupivacaine 10 mg/kg + perineurald exam ethasone 0.5 mg/kg-2nd day), Group 8 (Intraneural bupivacaine 10 mg/kg + perineural dexamethasone 0.5 mg/kg-7th day), Group 9 (Control group). At the end of the application period, histopathological and immunohistochemical examinations were analyzed. It was observed that caspase 3 levels significantly increased in the 5th and 6th groups compared to the 1st and 2nd groups (p