13C-Urea Breath Test for the Diagnosis of H. pylori Infection in Patients after Partial Gastrectomy: A Systematic Review and Meta-Analysis

• Published in: Journal of investigative surgery 2022-05, Vol.35 (5), p.1125-1134
• Main Authors: Chen, Zehua, Liu, Handong, Zhang, Yuexin, Jin, Tao, Hu, Jiankun, Yang, Kun
• Format: Article
• Language: English
• Subjects: 13c-urea breath test; Breath Tests; C-urea breath test; Carbon Isotopes; gastrectomy; Gastrectomy - adverse effects; Gastric Stump; gastroenterology; H. pylori; Helicobacter Infections - diagnosis; Helicobacter pylori; Humans; meta-analysis; Sensitivity and Specificity; Urea
• ISSN: 0894-1939; 1521-0553
• DOI: 10.1080/08941939.2021.1972185

The 13 C-urea breath test ( 13 C-UBT) is a kind of safe, noninvasive, and reliable measure for Helicobacter pylori (H. pylori) infection diagnosis in patients with complete stomach. Nevertheless, the test has not indicated fully precision in people who have had a gastrectomy. So, we made the use of a systematic review of plentiful published resources and research and meta-analysis. There are prominent research achievements regarding of utilizing 13 C-UBT for H. pylori infection patients diagnosis with the residual stomach. We searched publications available on Cochrane, PubMed, and Embase databases, and on the web of science. The last search was performed in May 2021. The basis model for this meta-analysis was fixed-effect through Metadisc Beta 1.4 software (Universidad Complutense, Madrid, Spain). When measuring the precision of 13 C-urea breath test, we utilized the ratio analysis such as Ratio of diagnostic odds ratio (DOR) and its corresponding 95% confidence interval (95%CI). Ten associated researches were analyzed with a total of 1065 patients. In general, the sensitivity of included studies ranged from 0.40 to 1.00 (I 2 = 81.2%), whereas the specificity ranged from 0.59 to 1.00 (I 2 = 90.1%). The pooled sensitivity, specificity were 0.83 (95% CI, 0.79-0.86; P