Airborne particulate matter from goat farm increases acute allergic airway responses in mice

Background: Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway...

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Bibliographic Details
Published in:Inhalation toxicology 2020-05, Vol.32 (6), p.265-277
Main Authors: Liu, Dingyu, Wagner, James G., Mariman, Rob, Harkema, Jack R., Gerlofs-Nijland, Miriam E., Pinelli, Elena, Folkerts, Gert, Cassee, Flemming R., Vandebriel, Rob J.
Format: Article
Language:English
Subjects:
Acute Disease
Air Pollutants - toxicity
Allergens
allergic airway disease
Animals
Asthma - genetics
Asthma - immunology
Asthma - pathology
BioPM
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - immunology
Cytokines - immunology
Eosinophils - immunology
Farms
Female
genomic pathways
goat farm
Goats
Immunoglobulin E - blood
Immunoglobulin G - blood
Lung - immunology
Lung - pathology
Mice, Inbred BALB C
murine
Neutrophils - immunology
Ovalbumin
Particulate Matter - toxicity
Th17
Th2
Transcriptome
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Summary:Background: Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway allergic responses. Methods: Fine (
ISSN:0895-8378
1091-7691
DOI:10.1080/08958378.2020.1781986