Expression of Insulin-like Growth Factors (IGF)-1 and -2, IGF-binding Proteins-2 and -3, and Receptors for Growth Hormone, IGF Type-1 and -2 and Insulin in the Gastrointestinal Tract of Neonatal Calves

• Published in: Growth factors (Chur, Switzerland) Switzerland), 2004-03, Vol.22 (1), p.63-69
• Main Authors: Ontsouka, E.C., Hammon, H.M., Blum, J.W.
• Format: Article
• Language: English
• Subjects: Animals; Animals, Newborn - metabolism; Calf; Cattle - metabolism; Colostrum; Gastrointestinal tract; Gastrointestinal Tract - metabolism; Gene Expression Regulation, Developmental; Growth hormone; Insulin-Like Growth Factor Binding Protein 2 - genetics; Insulin-Like Growth Factor Binding Protein 2 - metabolism; Insulin-Like Growth Factor Binding Protein 3 - genetics; Insulin-Like Growth Factor Binding Protein 3 - metabolism; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - metabolism; Insulin-Like Growth Factor II - genetics; Insulin-Like Growth Factor II - metabolism; Insulin-like growth factors; mRNA; Nutrition; Polymerase Chain Reaction; Receptor, IGF Type 1 - analysis; Receptor, IGF Type 1 - genetics; Receptor, IGF Type 2 - analysis; Receptor, IGF Type 2 - genetics; Receptor, Insulin - analysis; Receptor, Insulin - genetics; Receptor, Insulin - metabolism; Receptors, Somatomedin - analysis; Receptors, Somatomedin - genetics; Receptors, Somatomedin - metabolism; RNA, Messenger - analysis; Time Factors
• ISSN: 0897-7194; 1029-2292
• DOI: 10.1080/08977190410001688696

Growth hormone (GH), insulin-like growth factors (IGFs) and insulin influence post-natal gastrointestinal development and function. We have measured by real-time PCR the mRNA levels of IGF-1 and -2, IGF-binding proteins (IGFBPs)-2 and -3, and receptors for GH, IGF type-1 and -2, and insulin in esophagus, rumen, fundus, pylorus, duodenum, jejunum, ileum and colon of calves on days 1 and 5 of life. Levels of mRNA of measured traits were different (P