REM sleep deprivation impairs muscle regeneration in rats

Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (...

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Bibliographic Details
Published in:Growth factors (Chur, Switzerland) Switzerland), 2017-01, Vol.35 (1), p.12-18
Main Authors: Mônico-Neto, Marcos, Dáttilo, Murilo, Ribeiro, Daniel Araki, Lee, Kil Sun, de Mello, Marco Túlio, Tufik, Sergio, Antunes, Hanna Karen Moreira
Format: Article
Language:English
Subjects:
IGF-1
muscle recovery
skeletal muscle
sleep loss
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Summary:Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers. Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration.
ISSN:0897-7194
1029-2292
DOI:10.1080/08977194.2017.1314277