Role of the BMP6 protein in breast cancer and other types of cancer

The BMP6 protein (Bone Morphogenetic Protein 6) is part of the superfamily of transforming growth factor-beta (TGF-β) ligands, participates in iron homeostasis, inhibits invasion by increasing adhesions and cell-cell type interactions and induces angiogenesis directly on vascular endothelial cells....

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Bibliographic Details
Published in:Growth factors (Chur, Switzerland) Switzerland), 2021-07, Vol.39 (1-6), p.1-13
Main Authors: García Muro, Andrea Marlene, García Ruvalcaba, Azaria, Rizo de la Torre, Lourdes del Carmen, Sánchez López, Josefina Yoaly
Format: Article
Language:English
Subjects:
Bone Morphogenetic Protein 6
metastasis
methylation
neoplasms
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Summary:The BMP6 protein (Bone Morphogenetic Protein 6) is part of the superfamily of transforming growth factor-beta (TGF-β) ligands, participates in iron homeostasis, inhibits invasion by increasing adhesions and cell-cell type interactions and induces angiogenesis directly on vascular endothelial cells. BMP6 is coded by a tumor suppressor gene whose subexpression is related to the development and cancer progression; during neoplastic processes, methylation is the main mechanism by which gene silencing occurs. This work presents a review on the role of BMP6 protein in breast cancer (BC) and other types of cancer. The studies carried out to date suggest the participation of the BMP6 protein in the epithelial-mesenchymal transition (EMT) phenotype, cell growth and proliferation; however, these processes are affected in a variable way in the different types of cancer, the methylated CpG sites in BMP6 gene promoter, as well as the interaction with other proteins could be the cause of such variation.
ISSN:0897-7194
1029-2292
DOI:10.1080/08977194.2021.1994964