Anti-aging and anti-microbial effects of melleolide on various types of yeast

The chronological lifespan (CLS) of the budding yeast Saccharomyces cerevisiae is a model for the aging of post-mitotic cells in higher eukaryotes. In this study, we found that the sesquiterpene aryl ester melleolide expands the CLS of budding yeast. In contrast, melleolide compromised the CLS of th...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2014-01, Vol.78 (3), p.455-457
Main Authors: Nakaya, Shigeru, Kobori, Hajime, Sekiya, Atsushi, Kawagishi, Hirokazu, Ushimaru, Takashi
Format: Article
Language:English
Subjects:
Aging - drug effects
Aging - genetics
anti-aging
anti-microbial
Armillaria - chemistry
budding yeast
fission yeast
Gene Expression Regulation, Fungal - drug effects
Longevity - drug effects
Longevity - genetics
melleolide
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - genetics
Schizosaccharomyces - drug effects
Schizosaccharomyces - genetics
Sesquiterpenes - administration & dosage
Sesquiterpenes - chemistry
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Summary:The chronological lifespan (CLS) of the budding yeast Saccharomyces cerevisiae is a model for the aging of post-mitotic cells in higher eukaryotes. In this study, we found that the sesquiterpene aryl ester melleolide expands the CLS of budding yeast. In contrast, melleolide compromised the CLS of the fission yeast Schizosaccharomyces pombe. This indicates that melleolide might have a potential anti-aging activity against some types of cell, and that it might be useful as a selective anti-fungal drug.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2014.885826