Synthesis and pharmacokinetic characterization of a pH-sensitive polyethylene glycol ginsenoside CK (PEG-CK) conjugate

The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at a...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2014-01, Vol.78 (3), p.466-468
Main Authors: Mathiyalagan, Ramya, Subramaniyam, Sathiyamoorthy, Kim, Yeon Ju, Natarajan, Sathishkumar, Min, Jin Woo, Kim, Se Young, Yang, Deok Chun
Format: Article
Language:English
Subjects:
cancer
Chromatography, High Pressure Liquid
compound k
Esters - chemistry
Ginsenosides - chemical synthesis
Ginsenosides - chemistry
Ginsenosides - pharmacokinetics
Hydrogen-Ion Concentration
Panax - chemistry
Panax ginseng
polyethylene glycol
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
solubility
Surface Properties
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Summary:The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2014.885827