SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations

Ebp2 is an assembly factor of the 60S ribosomal subunit in yeast. We demonstrate that overexpression of SMY2 or SYH1 partially suppresses defects in growth and ribosome biogenesis of ebp2 mutants, and that smy2Δ and syh1Δ exhibit synthetic growth defects with the ebp2 allele. These results suggest t...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2015-09, Vol.79 (9), p.1481-1483
Main Authors: Okano, Akira, Wan, Kun, Kanda, Kazuhiro, Yabuki, Yukari, Funato, Kouichi, Mizuta, Keiko
Format: Article
Language:English
Subjects:
Carrier Proteins - genetics
EBP2
Mutation
Ribosomal Proteins
ribosome biogenesis
Ribosome Subunits, Large, Eukaryotic - genetics
Ribosomes - genetics
RNA, Ribosomal - genetics
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae Proteins - genetics
SMY2
SYH1
Vesicular Transport Proteins - genetics
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Summary:Ebp2 is an assembly factor of the 60S ribosomal subunit in yeast. We demonstrate that overexpression of SMY2 or SYH1 partially suppresses defects in growth and ribosome biogenesis of ebp2 mutants, and that smy2Δ and syh1Δ exhibit synthetic growth defects with the ebp2 allele. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2015.1031077