Isolation, structural identification and biological characterization of two conopeptides from the Conus pennaceus venom

A novel anti-mollusk conopeptide pn4c was isolated from the Conus pennaceus venom by repeated HPLC fractionation based on the activity against freshwater snails. The primary structure of pn4c was determined by the mass spectrometric de novo sequencing analysis. In addition, pn3a was isolated from th...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2017-11, Vol.81 (11), p.2086-2089
Main Authors: Abdel-Wahab, Mohammed, Miyashita, Masahiro, Ota, Yoshiyuki, Juichi, Hironori, Okabe, Ryota, Sarhan, Moustafa, Fouda, Maged, Abdel-Rahman, Mohamed, Saber, Samy, Nakagawa, Yoshiaki
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
anti-mollusk toxicity
cone snail
Conus Snail - chemistry
mass spectrometry
peptide toxin
Peptides - chemistry
Peptides - isolation & purification
Peptides - metabolism
venom
Venoms - chemistry
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Summary:A novel anti-mollusk conopeptide pn4c was isolated from the Conus pennaceus venom by repeated HPLC fractionation based on the activity against freshwater snails. The primary structure of pn4c was determined by the mass spectrometric de novo sequencing analysis. In addition, pn3a was isolated from the same fraction containing pn4c, as a peptide with unknown functions.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2017.1364966