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Dietary daidzein decreases food intake accompanied with delayed gastric emptying in ovariectomized rats
We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietar...
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| Published in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-06, Vol.84 (6), p.1232-1238 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c478t-ea002730a109863f7a4771f5fc0adaa9872fefe504870932046feb814361727f3 |
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| cites | cdi_FETCH-LOGICAL-c478t-ea002730a109863f7a4771f5fc0adaa9872fefe504870932046feb814361727f3 |
| container_end_page | 1238 |
| container_issue | 6 |
| container_start_page | 1232 |
| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 84 |
| creator | Adhikari, Sudhashree Bhattarai, Keshab Abe, Yasuhiro Kira, Mayu Fujitani, Mina Miyada, Tomihiro Kishida, Taro |
| description | We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietary daidzein may be attributed to delayed gastric emptying. Results suggest that dietary daidzein delays gastric emptying and that it has an anorectic effect with residual gastric contents, but not without gastric contents. Dietary equol significantly decreased daily food intake in the OVX rats without sleeve gastrectomy, but not in those with sleeve gastrectomy, suggesting that the accumulation of food in the stomach is required for the anorectic effect of equol to occur. These results support the hypothesis that the anorectic effect of dietary daidzein is attributed to delayed gastric emptying.
Dietary daidzein delays gastric emptying, and has an anorectic effect with residual gastric contents, but not without gastric contents. |
| doi_str_mv | 10.1080/09168451.2020.1723404 |
| format | article |
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Dietary daidzein delays gastric emptying, and has an anorectic effect with residual gastric contents, but not without gastric contents.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1080/09168451.2020.1723404</identifier><identifier>PMID: 32067573</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; anorectic effect ; Appetite Depressants - pharmacology ; Daidzein ; Dietary Supplements ; Eating - drug effects ; Equol - pharmacology ; Female ; Gastrectomy ; gastric emptying ; Gastric Emptying - drug effects ; Gastroparesis - chemically induced ; Isoflavones - pharmacology ; Ovariectomy ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2020-06, Vol.84 (6), p.1232-1238</ispartof><rights>2020 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-ea002730a109863f7a4771f5fc0adaa9872fefe504870932046feb814361727f3</citedby><cites>FETCH-LOGICAL-c478t-ea002730a109863f7a4771f5fc0adaa9872fefe504870932046feb814361727f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32067573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adhikari, Sudhashree</creatorcontrib><creatorcontrib>Bhattarai, Keshab</creatorcontrib><creatorcontrib>Abe, Yasuhiro</creatorcontrib><creatorcontrib>Kira, Mayu</creatorcontrib><creatorcontrib>Fujitani, Mina</creatorcontrib><creatorcontrib>Miyada, Tomihiro</creatorcontrib><creatorcontrib>Kishida, Taro</creatorcontrib><title>Dietary daidzein decreases food intake accompanied with delayed gastric emptying in ovariectomized rats</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietary daidzein may be attributed to delayed gastric emptying. Results suggest that dietary daidzein delays gastric emptying and that it has an anorectic effect with residual gastric contents, but not without gastric contents. Dietary equol significantly decreased daily food intake in the OVX rats without sleeve gastrectomy, but not in those with sleeve gastrectomy, suggesting that the accumulation of food in the stomach is required for the anorectic effect of equol to occur. These results support the hypothesis that the anorectic effect of dietary daidzein is attributed to delayed gastric emptying.
Dietary daidzein delays gastric emptying, and has an anorectic effect with residual gastric contents, but not without gastric contents.</description><subject>Animals</subject><subject>anorectic effect</subject><subject>Appetite Depressants - pharmacology</subject><subject>Daidzein</subject><subject>Dietary Supplements</subject><subject>Eating - drug effects</subject><subject>Equol - pharmacology</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>gastric emptying</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastroparesis - chemically induced</subject><subject>Isoflavones - pharmacology</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOwzAQRS0EoqXwCaD8QMo4duJkBypPqRIbWEdTxy6GJo5sF5R-Pa7askSsRjM690pzCLmkMKVQwjVUtCh5TqcZZPEkMsaBH5ExZVykRcXFMRlvmXQLjciZ9x8A8ZDTUzJiGRQiF2xMlndGBXRD0qBpNsp0SaOkU-iVT7S1TWK6gJ8qQSlt22NnVJN8m_AesRUOcVmiD87IRLV9GEy3jIHEfqEzSgbbmk1EHAZ_Tk40rry62M8JeXu4f509pfOXx-fZ7TyVXJQhVQiQCQZIoSoLpgVyIajOtQRsEKtSZFpplQMvBVTxDV5otSgpZ0VUIDSbkHzXK5313ild98608cGaQr0VVx_E1Vtx9V5czF3tcv160armN3UwFQHYAXbd_7vzZhcxnbauxW_rVk0dcFhZpx120via_V3xA8Jai7U</recordid><startdate>20200602</startdate><enddate>20200602</enddate><creator>Adhikari, Sudhashree</creator><creator>Bhattarai, Keshab</creator><creator>Abe, Yasuhiro</creator><creator>Kira, Mayu</creator><creator>Fujitani, Mina</creator><creator>Miyada, Tomihiro</creator><creator>Kishida, Taro</creator><general>Taylor & Francis</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200602</creationdate><title>Dietary daidzein decreases food intake accompanied with delayed gastric emptying in ovariectomized rats</title><author>Adhikari, Sudhashree ; Bhattarai, Keshab ; Abe, Yasuhiro ; Kira, Mayu ; Fujitani, Mina ; Miyada, Tomihiro ; Kishida, Taro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-ea002730a109863f7a4771f5fc0adaa9872fefe504870932046feb814361727f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>anorectic effect</topic><topic>Appetite Depressants - pharmacology</topic><topic>Daidzein</topic><topic>Dietary Supplements</topic><topic>Eating - drug effects</topic><topic>Equol - pharmacology</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>gastric emptying</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastroparesis - chemically induced</topic><topic>Isoflavones - pharmacology</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adhikari, Sudhashree</creatorcontrib><creatorcontrib>Bhattarai, Keshab</creatorcontrib><creatorcontrib>Abe, Yasuhiro</creatorcontrib><creatorcontrib>Kira, Mayu</creatorcontrib><creatorcontrib>Fujitani, Mina</creatorcontrib><creatorcontrib>Miyada, Tomihiro</creatorcontrib><creatorcontrib>Kishida, Taro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adhikari, Sudhashree</au><au>Bhattarai, Keshab</au><au>Abe, Yasuhiro</au><au>Kira, Mayu</au><au>Fujitani, Mina</au><au>Miyada, Tomihiro</au><au>Kishida, Taro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary daidzein decreases food intake accompanied with delayed gastric emptying in ovariectomized rats</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2020-06-02</date><risdate>2020</risdate><volume>84</volume><issue>6</issue><spage>1232</spage><epage>1238</epage><pages>1232-1238</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietary daidzein may be attributed to delayed gastric emptying. Results suggest that dietary daidzein delays gastric emptying and that it has an anorectic effect with residual gastric contents, but not without gastric contents. Dietary equol significantly decreased daily food intake in the OVX rats without sleeve gastrectomy, but not in those with sleeve gastrectomy, suggesting that the accumulation of food in the stomach is required for the anorectic effect of equol to occur. These results support the hypothesis that the anorectic effect of dietary daidzein is attributed to delayed gastric emptying.
Dietary daidzein delays gastric emptying, and has an anorectic effect with residual gastric contents, but not without gastric contents.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32067573</pmid><doi>10.1080/09168451.2020.1723404</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Bioscience, biotechnology, and biochemistry, 2020-06, Vol.84 (6), p.1232-1238 |
| issn | 0916-8451 1347-6947 |
| language | eng |
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| source | Oxford Journals Online; EZB Electronic Journals Library |
| subjects | Animals anorectic effect Appetite Depressants - pharmacology Daidzein Dietary Supplements Eating - drug effects Equol - pharmacology Female Gastrectomy gastric emptying Gastric Emptying - drug effects Gastroparesis - chemically induced Isoflavones - pharmacology Ovariectomy Rats Rats, Sprague-Dawley |
| title | Dietary daidzein decreases food intake accompanied with delayed gastric emptying in ovariectomized rats |
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