Analysis of 130 Cases of Sympathetic Ophthalmia - A Retrospective Multicenter Case Series

Objective: To analyze the demographic profile, treatment, and visual outcome of the patients with sympathetic ophthalmia (SO) in a multicenter collaborative retrospective cohort study. Methods: Medical records of the patients with SO from UK, Singapore, India were reviewed for history of ocular trau...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2019-11, Vol.27 (8), p.1259-1266
Main Authors: Tan, Xiu Ling, Seen, Sophia, Dutta Majumder, Parthopratim, Ganesh, Sudha K., Agarwal, Mamta, Soni, Aniruddh, Biswas, Jyotirmay, Aggarwal, Kanika, Mahendradas, Padmamalini, Gupta, Vishali, Ling, Ho Su, Teoh, Stephen, Pavesio, Carlos, Agrawal, Rupesh
Format: Article
Language:English
Subjects:
Adult
Corticosteroids
Disease Management
enucleation
Eye Enucleation
Female
Glucocorticoids - therapeutic use
Humans
Immunologic Factors - therapeutic use
Immunosuppressive Agents - therapeutic use
immunosuppressive therapy
Incidence
India - epidemiology
Male
Middle Aged
Ophthalmia, Sympathetic - diagnosis
Ophthalmia, Sympathetic - epidemiology
Ophthalmia, Sympathetic - therapy
phthisis bulbi
Prognosis
Retrospective Studies
Singapore - epidemiology
sympathetic ophthalmia
trauma
United Kingdom - epidemiology
Visual Acuity
Vitreoretinal Surgery - methods
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Summary:Objective: To analyze the demographic profile, treatment, and visual outcome of the patients with sympathetic ophthalmia (SO) in a multicenter collaborative retrospective cohort study. Methods: Medical records of the patients with SO from UK, Singapore, India were reviewed for history of ocular trauma or surgery and subsequent development of uveitis consistent with SO, presenting symptoms, treatment, and visual outcomes. Results: A total of 130 patients were diagnosed with SO during the study period. Eighty-one (62.3%) patients were men. The mean age was 48.4 ± 15.5 years. The most common presenting symptom was blurring of vision (89.2%), followed by pain (29.2%) and floaters (23.8%). Ninety-two (70.7%) required additional immunosuppressive therapy. Thirty-six (27.9%) patients underwent enucleation of the inciting eye. Conclusions: SO is a potentially sight-threatening disease with high rates of visual loss. It warrants prompt evaluation and treatment. With the advances and availability in immunotherapy, the visual prognosis is relatively good.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2018.1517894