Intra-silicone Oil Injection of Methotrexate in Retinal Reattachment Surgery for Proliferative Vitreoretinopathy

Purpose: To evaluate the role of intrasilicone oil injection of methotrexate (MTX) at the end of vitrectomy surgery for rhegmatogenous retinal detachment (RRD) associated with proliferative vitreoretinopathy (PVR). Methods: In this prospective comparative study, pars plana vitrectomy and retinal rea...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2020-04, Vol.28 (3), p.513-516
Main Authors: Falavarjani, Khalil Ghasemi, Hadavandkhani, Ali, Parvaresh, Mohammad Mehdi, Modarres, Mehdi, Naseripour, Masood, Alemzadeh, Sayyed Amirpooya
Format: Article
Language:English
Subjects:
Endotamponade - methods
Female
Follow-Up Studies
Humans
Immunosuppressive Agents - administration & dosage
Injections, Intraocular
Male
Methotrexate
Methotrexate - administration & dosage
Middle Aged
pars plana vitrectomy
proliferative vitreoretinopathy
Prospective Studies
Retinal Detachment - etiology
Retinal Detachment - surgery
rhegmatogenous retinal detachment
Silicone Oils
Visual Acuity
Vitrectomy - methods
Vitreoretinopathy, Proliferative - complications
Vitreoretinopathy, Proliferative - diagnosis
Vitreoretinopathy, Proliferative - therapy
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Summary:Purpose: To evaluate the role of intrasilicone oil injection of methotrexate (MTX) at the end of vitrectomy surgery for rhegmatogenous retinal detachment (RRD) associated with proliferative vitreoretinopathy (PVR). Methods: In this prospective comparative study, pars plana vitrectomy and retinal reattachment were performed for eyes with RRD with grade C PVR. In the MTX group, 250 µg MTX was injected into the silicone oil at the end of surgery. The rate of retinal redetachment associated with PVR was assessed. Results: In total, 44 eyes of 44 patients (22 in the MTX group and 22 controls) were included. Baseline characteristics were similar between the two groups. Retinal redetachment occurred in one eye (4.5%) in the MTX group and five eyes (22.7%) in the control group (p = 0.18). The change in visual acuity was similar between the two groups at final visit (p = 0.15). Conclusion: The rate of redetachment associated with PVR was lower after intrasilicone injection of MTX at the end of vitrectomy for RRD with severe PVR compared to control group; however, the difference was not statistically significant.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2019.1597894