Role of Optical Coherence Tomography in the Prognosis of Vogt-Koyanagi-Harada Disease

Purpose: To evaluate the prognostic value of OCT in acute VKH disease Methods: Retrospective series of consecutive VKH patients seen with the first presentation, a minimum follow-up of 1 year and serial OCT imaging. The primary outcome was the clinical activity phase at 1, 2 and 3 years. Results: Am...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2021-01, Vol.29 (1), p.118-123
Main Authors: Chee, Soon-Phaik, Afrin, Mafruha, Tumulak, Mayjane JG, Siak, Jay
Format: Article
Language:English
Subjects:
Choroidal inflammation
immunosuppression
inflammation
non-infectious chorioretinopathies
Panuveitis
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Summary:Purpose: To evaluate the prognostic value of OCT in acute VKH disease Methods: Retrospective series of consecutive VKH patients seen with the first presentation, a minimum follow-up of 1 year and serial OCT imaging. The primary outcome was the clinical activity phase at 1, 2 and 3 years. Results: Among 29 subjects, 7 resolved, 17 became chronic, and 5 developed chronic recurrent VKH. Median RNFL measurement obtained 2 months post-treatment was higher among subjects who developed chronic VKH (p-value = 0.03) and chronic recurrent disease (p-value = 0.04). Median CRT 1-week post-treatment was lower among subjects who developed PPA (p-value = 0.03). CRT 2 months post-treatment was higher among subjects who developed vitiligo (p-value = 0.02). Conclusion: OCT is helpful in early recognition of the predominantly optic disc swelling variant which carries a poorer prognosis. Lower CRT reading at 1 week and persistently raised CRT at 2 months post-treatment correlated with chronic recurrent disease.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2019.1655580