Murine chronotoxicity to pharmaceutical wastewater

The present study was undertaken to report the modeling of the dosing-time-dependent adverse effects of both untreated and biologically-treated pharmaceutical wastewater in mice. The mice were housed in a room controlled at 24 °C under a 12 h/12 h dark-light cycle (light 7:00–19:00 h) for two weeks...

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Bibliographic Details
Published in:Biological rhythm research 2014-03, Vol.45 (2), p.167-181
Main Authors: Dridi, Dorra, Bchir, Fatma, Zouiten, Amina, Tahrani, Leyla, Ben Mansour, Hedi
Format: Article
Language:English
Subjects:
adverse effects
ataxia (disorder)
bioremediation
body weight changes
chronotoxicity
circadian rhythm
drugs
mice
pharmaceutical wastewater
photoperiod
Pseudomonas putida
survival rate
toxicity
wastewater
weight loss
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Summary:The present study was undertaken to report the modeling of the dosing-time-dependent adverse effects of both untreated and biologically-treated pharmaceutical wastewater in mice. The mice were housed in a room controlled at 24 °C under a 12 h/12 h dark-light cycle (light 7:00–19:00 h) for two weeks before initiating the experiments and allowed free access to food and water. A single dose of pharmaceutical or bioremediated effluent was administrated intraperitoneally (10 mL/kg) to mice divided in six circadian stages [1, 5, 9, 13, 17, and 21 hours after light onset (HALO)]. The surviving treated mice exhibited a significant circadian variation in body weight loss (p
ISSN:1744-4179
0929-1016
1744-4179
DOI:10.1080/09291016.2013.787684