Murine chronotoxicity to pharmaceutical wastewater

The present study was undertaken to report the modeling of the dosing-time-dependent adverse effects of both untreated and biologically-treated pharmaceutical wastewater in mice. The mice were housed in a room controlled at 24 °C under a 12 h/12 h dark-light cycle (light 7:00–19:00 h) for two weeks...

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Published in:Biological rhythm research 2014-03, Vol.45 (2), p.167-181
Main Authors: Dridi, Dorra, Bchir, Fatma, Zouiten, Amina, Tahrani, Leyla, Ben Mansour, Hedi
Format: Article
Language:English
Subjects:
adverse effects
ataxia (disorder)
bioremediation
body weight changes
chronotoxicity
circadian rhythm
drugs
mice
pharmaceutical wastewater
photoperiod
Pseudomonas putida
survival rate
toxicity
wastewater
weight loss
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container_title Biological rhythm research
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creator Dridi, Dorra
Bchir, Fatma
Zouiten, Amina
Tahrani, Leyla
Ben Mansour, Hedi
description The present study was undertaken to report the modeling of the dosing-time-dependent adverse effects of both untreated and biologically-treated pharmaceutical wastewater in mice. The mice were housed in a room controlled at 24 °C under a 12 h/12 h dark-light cycle (light 7:00–19:00 h) for two weeks before initiating the experiments and allowed free access to food and water. A single dose of pharmaceutical or bioremediated effluent was administrated intraperitoneally (10 mL/kg) to mice divided in six circadian stages [1, 5, 9, 13, 17, and 21 hours after light onset (HALO)]. The surviving treated mice exhibited a significant circadian variation in body weight loss (p
doi_str_mv 10.1080/09291016.2013.787684
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The mice were housed in a room controlled at 24 °C under a 12 h/12 h dark-light cycle (light 7:00–19:00 h) for two weeks before initiating the experiments and allowed free access to food and water. A single dose of pharmaceutical or bioremediated effluent was administrated intraperitoneally (10 mL/kg) to mice divided in six circadian stages [1, 5, 9, 13, 17, and 21 hours after light onset (HALO)]. The surviving treated mice exhibited a significant circadian variation in body weight loss (p &lt; 0.001). Pharmaceutical wastewater dosing at 17 HALO resulted in −6.5% weight loss, whereas drug dosing at 9 HALO was + 1.2% (Ф = 19.42 HALO ± 1.25 h, p &lt; 0.01). Only on the dark span, the proportion of dead mice was dosing-time-dependent (χ ² = 12.7; p &lt; 0.001). Pharmaceutical wastewater dosing at 17 HALO resulted in the poorest (67%) survival rate; whereas, the best survival was noted in the rest span with 100%. Troughs of motor incoordination were located at the administration times of 9 and 21 HALO (16% of animals affected), whereas peaks were located at 5 and 17 HALO (38 and 55% of animals affected, respectively). A statistically significant ultradian component rhythm with a trial period = 12 h, was detected by cosinor (p &lt; 0.009) the Ф = 17.00 HALO ± 1.70 h modulo 12 h. The toxicity was totally removed when the mice were treated by the bioremediated effluent. This indicates that Pseudomonas putida was able to completely detoxify the toxic pharmaceutical effluent. 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Troughs of motor incoordination were located at the administration times of 9 and 21 HALO (16% of animals affected), whereas peaks were located at 5 and 17 HALO (38 and 55% of animals affected, respectively). A statistically significant ultradian component rhythm with a trial period = 12 h, was detected by cosinor (p &lt; 0.009) the Ф = 17.00 HALO ± 1.70 h modulo 12 h. The toxicity was totally removed when the mice were treated by the bioremediated effluent. This indicates that Pseudomonas putida was able to completely detoxify the toxic pharmaceutical effluent. With regards to these data, the optimal tolerance to untreated pharmaceutical wastewater occurred in the light-rest span of mice.</abstract><pub>Taylor &amp; Francis</pub><doi>10.1080/09291016.2013.787684</doi><tpages>15</tpages></addata></record>
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subjects adverse effects
ataxia (disorder)
bioremediation
body weight changes
chronotoxicity
circadian rhythm
drugs
mice
pharmaceutical wastewater
photoperiod
Pseudomonas putida
survival rate
toxicity
wastewater
weight loss
title Murine chronotoxicity to pharmaceutical wastewater
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