Circulating omentin-1 levels in women with polycystic ovary syndrome: a meta-analysis

To investigate the association between circulating omentin-1 levels and polycystic ovary syndrome (PCOS) in women, a meta-analysis was performed. A systematic literature search using PubMed, Embase and Web of Science was carried out. Ten articles with 13 studies were included in this meta-analysis,...

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Bibliographic Details
Published in:Gynecological endocrinology 2017-03, Vol.33 (3), p.244-249
Main Authors: Tang, Yun-Liang, Yu, Jiao, Zeng, Zhen-Guo, Liu, Ying, Liu, Jian-Ying, Xu, Ji-Xiong
Format: Article
Language:English
Subjects:
Adipokine
Adult
Cytokines - blood
Down-Regulation
Female
GPI-Linked Proteins - blood
Humans
Insulin Resistance
Lectins - blood
meta-analysis
Obesity - blood
Obesity - complications
omentin-1
Overweight - blood
Overweight - complications
polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Reproducibility of Results
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Summary:To investigate the association between circulating omentin-1 levels and polycystic ovary syndrome (PCOS) in women, a meta-analysis was performed. A systematic literature search using PubMed, Embase and Web of Science was carried out. Ten articles with 13 studies were included in this meta-analysis, which included a total of 1264 subjects (733 patients with PCOS and 531 controls). The pooled standard mean difference (SMD) and 95% confidence interval (CI) were used to estimate the association between omentin-1 levels and PCOS. Circulating omentin-1 levels were lower in PCOS with an SMD (95% CI) of −0.67 (−0.91, −0.43) and p = 0.000 (random-effects). However, significant heterogeneity was detected across studies (I 2 =73.6% and p = 0.000). The subgroup analysis suggested that omentin-1 levels in PCOS patients were associated with HOMA-IR ratio. Meta-regression analysis indicated region was the main source of heterogeneity (p = 0.048). The results of this meta-analysis suggested that circulating omentin-1 levels are significantly lower in women with PCOS compared with controls, which indicated that omentin-1 may play a role in the pathologic processes of PCOS.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2016.1254180