Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?

Aim: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. Materials and methods: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (...

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Published in:Gynecological endocrinology 2018-02, Vol.34 (2), p.157-160
Main Authors: Gorkem, Umit, Togrul, Cihan, Arslan, Emine, Sargin Oruc, Ayla, Buyukkayaci Duman, Nuriye
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Cross-Sectional Studies
Dehydroepiandrosterone Sulfate - blood
Female
Follicle Stimulating Hormone - blood
Hospitals, University
Humans
Infertility, Female - etiology
Kisspeptin
Kisspeptins - blood
Outpatient Clinics, Hospital
Ovarian Reserve
Overweight - complications
polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - physiopathology
Prospective Studies
Severity of Illness Index
Testosterone - blood
Turkey
Up-Regulation
Young Adult
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Summary:Aim: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. Materials and methods: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured. The blood samples were analyzed for estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), 17-hydroxy progesterone (17OHP), dehydroepiandrosterone sulfate (DHEAS), antimullerian hormone (AMH), kisspeptin measurements. Results: FSH concentration was higher and AMH concentration was lower in DOR group (p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2017.1379499