Androgen profile in young females with insulin resistance; the importance of 17-Hydroxyprogesterone: Androgens in young insulin resistant females

Considerable researches on sex steroids and insulin action have suggested a mutual interaction between hyperandrogenemia and insulin resistance (IR). The objective of present study was to evaluate the androgens levels in young females with emphasis on the association of 17OHP with IR. Serum concentr...

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Bibliographic Details
Published in:Gynecological endocrinology 2019-12, Vol.35 (12), p.1094-1098
Main Authors: Basaki, Mehdi, Saeb, Mehdi, Saeb, Saeedeh
Format: Article
Language:English
Subjects:
17-alpha-Hydroxyprogesterone - metabolism
17-hydroxyprogesterone
Adult
Androgen
Androgens - metabolism
androstenedione
Androstenedione - metabolism
Blood Glucose - metabolism
Case-Control Studies
dehydroepiandrosterone
Dehydroepiandrosterone Sulfate - metabolism
Dihydrotestosterone - metabolism
Female
Humans
Insulin - metabolism
Insulin Resistance
testosterone
Testosterone - metabolism
Young Adult
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Summary:Considerable researches on sex steroids and insulin action have suggested a mutual interaction between hyperandrogenemia and insulin resistance (IR). The objective of present study was to evaluate the androgens levels in young females with emphasis on the association of 17OHP with IR. Serum concentrations of glucose, insulin, and androgens in 80 young females were measured by standard routine procedures. Total testosterone (TT), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEAS), androstenedione (ASD), and 17-hydroxyprogesterone (17OHP) levels were higher in patients with IR compared to healthy controls (p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2019.1630377