The role of oxidative stress on subclinical atherosclerosis in premature ovarian insufficiency and relationship with carotid intima-media thickness

Objective: We aimed to investigate the relationship between oxidative stress (OS) and subclinical atherosclerosis in patients with premature ovarian insufficiency (POI), by analyzing the dynamic thiol/disulfide homeostasis (TDH) parameters as an OS marker and carotid intima-media thickness (CIMT). M...

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Published in:Gynecological endocrinology 2020-08, Vol.36 (8), p.687-692
Main Authors: Bozkaya, Veciha Özlem, Yumusak, Omer Hamid, Ozaksit, Gulnur, Tenekecioğlu, Erhan, Gül Ibrişim, Ece, Alkan, Mihriban, Oskovi-Kaplan, Z. Aslı, Erel, Özcan
Format: Article
Language:English
Subjects:
oxidative stress
Premature ovarian insufficiency
subclinical atherosclerosis
thiol/disulfide homeostasis
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Summary:Objective: We aimed to investigate the relationship between oxidative stress (OS) and subclinical atherosclerosis in patients with premature ovarian insufficiency (POI), by analyzing the dynamic thiol/disulfide homeostasis (TDH) parameters as an OS marker and carotid intima-media thickness (CIMT). Materials and methods: A total of 69 women, 34 with POI and 35 healthy controls were included in this prospective cross-sectional study. TDH parameters (plasma native thiol, total thiol, disulfide, disulfide/native thiol, native thiol/total thiol, and disulfide/total thiol ratios) and CIMT were measured and compared between the two groups. Results: In primary ovarian insufficiency group, native thiol (p=.009) and total thiol (p=.010) levels were significantly decreased, and CIMT values were significantly increased (p= 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2020.1766439