Could sestrin protein in serum be a new marker of oxidative stress in patients with polycystic ovary syndrome?

PCOS (polycystic ovary syndrome) is one of the most common endocrinological disorders and it is the threshold of many systemic disorders. There are many studies in the literature on the mechanisms that cause increased oxidation in PCOS. Sestrin protein is known to regulate the oxidation. In this stu...

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Bibliographic Details
Published in:Gynecological endocrinology 2022-12, Vol.38 (12), p.1109-1113
Main Authors: Bestel, Aysegul, Elmas, Burak, Günkaya, Osman Samet, Bestel, Melih, Bahat, Pınar Yalçın
Format: Article
Language:English
Subjects:
Female
Humans
Hyperandrogenemia
menstrual irregularity
oxidative stress
polycystic ovary
Polycystic Ovary Syndrome
ROC Curve
sestrin
Sestrins
sestrin蛋白
多囊卵巢
月经失调
氧化应激
高雄激素血症
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Summary:PCOS (polycystic ovary syndrome) is one of the most common endocrinological disorders and it is the threshold of many systemic disorders. There are many studies in the literature on the mechanisms that cause increased oxidation in PCOS. Sestrin protein is known to regulate the oxidation. In this study, it is aimed to examine the changes in the level of sestrin protein in women with PCOS. A total of 60 women participated the study, 30 of whom were diagnosed with PCOS according to the Rotterdam criteria. Also, 30 women were included in the study as the control group. Demographic information, biochemical analysis results, and sestrin levels of the patients in each group were compared. The median sestrin level was 6.2 ± 0.8 in the PCOS group and 3.38 ± 0.4 in the control group (p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2022.2163234