Neonatal platelets from cord blood and peripheral blood

The haemostatic system in neonates is different from that of adults, possibly contributing to an increased incidence of bleeding disorders, such as intracranial hemorrhage. In this study, we analyzed platelets from cord blood and peripheral blood, collected at three time points after delivery from 2...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2005-05, Vol.16 (3-4), p.203-210
Main Authors: Sitaru, A.G., Holzhauer, S., Speer, C.P., Singer, D., Obergfell, A., Walter, U., Grossmann, R.
Format: Article
Language:English
Subjects:
Acid Phosphatase - pharmacology
Adult
Blood Cells - cytology
Blood Platelets - chemistry
Blood Platelets - physiology
Cell Degranulation
Dual Specificity Phosphatase 2
Fetal Blood - cytology
Flow Cytometry
Gestational Age
Humans
Infant, Newborn
Isoenzymes - pharmacology
Neonates
P-Selectin - analysis
Platelet Glycoprotein GPIIb-IIIa Complex - analysis
Platelet Membrane Glycoproteins - analysis
platelet reactivity
platelets
Premature Birth
Protein Phosphatase 2
Protein Tyrosine Phosphatases - metabolism
Tartrate-Resistant Acid Phosphatase
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Summary:The haemostatic system in neonates is different from that of adults, possibly contributing to an increased incidence of bleeding disorders, such as intracranial hemorrhage. In this study, we analyzed platelets from cord blood and peripheral blood, collected at three time points after delivery from 20 term and 37 preterm neonates as well as blood from 20 healthy adults. Platelet membrane glycoproteins (GP) were quantified and P-selectin expression and PAC-1 binding ability before and after stimulation with TRAP were analyzed by whole blood flow cytometry. We found no significant differences in neonatal platelets from cord blood and peripheral blood within the first 24 h of life. Platelets from infants less than 30 weeks of gestation expressed lower levels of GP (33271 ± 9381 vs. 44085 ± 17287 for GPIIIa, P 
ISSN:0953-7104
1369-1635
DOI:10.1080/09537100400016862