Risk factors and clinical outcome of profound thrombocytopenia in adult patients with DENV infections

Severe thrombocytopenia is common in dengue virus (DENV) infections. However, studies focusing on the role of profound thrombocytopenia (PT) (nadir platelet counts ≤ 20 000/mm 3 ) in DENV infections are scarce. This study aims to identify the associated features and outcome of DENV patients with PT....

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Bibliographic Details
Published in:Platelets (Edinburgh) 2017-10, Vol.28 (7), p.724-727
Main Authors: Dhanoa, Amreeta, Rajasekaram, Ganeswrie, Hassan, Sharifah Syed, Ramadas, Amutha, Azreen Adnan, Nur Amelia, Lau, Chun Fatt, Chan, Teik Seng, Ngim, Chin Fang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Blood Platelets - metabolism
Blood Platelets - pathology
Dengue
Dengue Virus - pathogenicity
Dengue Virus - physiology
DENV infections
Female
Hematocrit
Hemorrhage - blood
Hemorrhage - pathology
Hospitalization
Humans
Logistic Models
Male
Middle Aged
Platelet Count
Retrospective Studies
Risk Factors
Serum Albumin - metabolism
Severe Dengue - blood
Severe Dengue - complications
Severe Dengue - pathology
Severity of Illness Index
thrombocytopenia
Thrombocytopenia - blood
Thrombocytopenia - complications
Thrombocytopenia - pathology
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Summary:Severe thrombocytopenia is common in dengue virus (DENV) infections. However, studies focusing on the role of profound thrombocytopenia (PT) (nadir platelet counts ≤ 20 000/mm 3 ) in DENV infections are scarce. This study aims to identify the associated features and outcome of DENV patients with PT. It involves 237 adult hospitalized patients who were DENV PCR positive. The presence of comorbidity (AOR = 4.625; 95% CI = 1.113-19.230), higher admission hematocrit (AOR = 1.213; 95% CI = 1.067-1.379), lower admission albumin (AOR = 0.870; 95% CI = 0.766-0.988) and lower admission platelets (AOR = 0.980; 95% CI = 0.969-0.991) was associated with platelets ≤ 20 000/mm 3 in multivariate logistic regression. PT was not affected by DENV serotypes, coinfections and secondary DENV infections. Patients with PT had significantly higher risk of experiencing warning signs (AOR = 3.709, 95% CI = 1.089-12.634) and longer hospital stay (AOR = 1.943, 95% CI = 1.010-3.774). However, severe dengue disease, hemorrhagic manifestations and need for intensive care were not significantly associated with PT.
ISSN:0953-7104
1369-1635
DOI:10.1080/09537104.2017.1293802