Fibrinogen levels are associated with bleeding in patients with primary immune thrombocytopenia

Bleeding is the most common clinical symptom and the leading cause of death in patients with primary immune thrombocytopenia (ITP). Our research intends to verify the role of fibrinogen levels as independent determinants of bleeding. We retrospectively analyzed the relationship between fibrinogen le...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2020-08, Vol.31 (6), p.763-770
Main Authors: Xu, Min, Luo, Lili, Du, Mengyi, Tang, Lu, Hu, Yu, Mei, Heng
Format: Article
Language:English
Subjects:
Bleeding
fibrinogen
platelet
primary immune thrombocytopenia
thrombocytopenia
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Summary:Bleeding is the most common clinical symptom and the leading cause of death in patients with primary immune thrombocytopenia (ITP). Our research intends to verify the role of fibrinogen levels as independent determinants of bleeding. We retrospectively analyzed the relationship between fibrinogen levels and bleeding events in 463 patients. Additionally, we confirmed the impact of fibrinogen level on clot firmness in 25 patients via thrombelastography (TEG). Fibrinogen levels (median and inter-quartile range, IQR) were significantly different (p
ISSN:0953-7104
1369-1635
DOI:10.1080/09537104.2019.1678115