Intravital imaging of megakaryocytes

The dynamics of platelet formation could only be investigated since the development of two-photon microscopy in combination with suitable fluorescent labeling strategies. In this review paper, we give an overview of recent advances in fluorescence imaging of the bone marrow that have contributed to...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2020-07, Vol.31 (5), p.599-609
Main Authors: Stegner, David, Heinze, Katrin G.
Format: Article
Language:English
Subjects:
Humans
Intravital imaging
Intravital Microscopy - methods
megakaryocytes
Megakaryocytes - cytology
Megakaryocytes - metabolism
thrombopoiesis
two-photon microscopy
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Summary:The dynamics of platelet formation could only be investigated since the development of two-photon microscopy in combination with suitable fluorescent labeling strategies. In this review paper, we give an overview of recent advances in fluorescence imaging of the bone marrow that have contributed to our understanding of platelet biogenesis during the last decade. We make a brief survey through the perspectives and limitations of today's intravital imaging, but also discuss complementary methods that may help to piece together the puzzle of megakaryopoiesis and platelet formation.
ISSN:0953-7104
1369-1635
DOI:10.1080/09537104.2020.1738366