The effect of humic substances on gut microbiota and immune response of broilers

The work focused on the study of the immunomodulatory and gut-protecting effect of humic substances (HS) in broilers. The diet of experimental chicks was enriched with 0.8% of HS. We noted that HS had a stimulatory effect on the phagocytic activity and the engulfing capacity of phagocytes, however,...

Full description

Saved in:
Bibliographic Details
Published in:Food and agricultural immunology 2020-01, Vol.31 (1), p.137-149
Main Authors: Mudroňová, D., Karaffová, V., Pešulová, T., Koščová, J., Maruščáková, I. Cingeľová, Bartkovský, M., Marcinčáková, D., Ševčíková, Z., Marcinčák, S.
Format: Article
Language:English
Subjects:
broilers
CD4 antigen
CD8 antigen
Chicks
Digestive system
Gastrointestinal tract
Gene expression
Growth factors
gut microbiota
Humic acids
Humic substances
Immune response
Immune system
immunity
Immunoglobulin A
Immunomodulation
Immunostimulation
Insulin
Insulin-like growth factors
Intestinal microflora
Intestine
Lymphocytes
Microbiota
Mucin
Phagocytes
Poultry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The work focused on the study of the immunomodulatory and gut-protecting effect of humic substances (HS) in broilers. The diet of experimental chicks was enriched with 0.8% of HS. We noted that HS had a stimulatory effect on the phagocytic activity and the engulfing capacity of phagocytes, however, the level of oxidative burst of phagocytes was not affected. We observed a significant increase of CD4+: CD8+ lymphocyte ratio, an indicator of immune stimulation. HS did not influence the IgA gene expression. In contrast, we observed a significant increase in the expression of MUC-2 (intestinal mucin 2) gene, and a decrease in the expression of IGF-2 (insulin-like growth factor 2) and also AvBD2 (avian beta defensin 2) genes. A decreased Enterobacteriaceae counts in the gut of experimental animals showed a positive effect on intestinal microbiota. We confirmed a gut-protecting and an immunostimulatory effect of HS in broiler chickens.
ISSN:0954-0105
1465-3443
DOI:10.1080/09540105.2019.1707780