Treatment and follow-up of persistent granulomatous cheilitis with intralesional steroid and metronidazole

Granulomatous cheilitis (GC) is a chronic edema which frequently affects the upper lip due to granulomatous inflammation. Its etiology is currently unknown. This rare disease is generally accompanied by Melkersson-Rosenthal syndrome (MRS), characterized by scrotal tongue, orofacial edema and facial...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2004-09, Vol.15 (5), p.333-335
Main Authors: Coskun, B, Saral, Y, Cicek, D, Akpolat, N
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug Therapy, Combination
Female
Glucocorticoids - administration & dosage
Granulomatous cheilitis
Humans
Injections, Intralesional
Intralesional corticosteroid
Lip - pathology
Medical sciences
Melkersson-Rosenthal syndrome
Melkersson-Rosenthal Syndrome - diagnosis
Melkersson-Rosenthal Syndrome - drug therapy
Melkersson-Rosenthal Syndrome - pathology
Metronidazole
Metronidazole - administration & dosage
Middle Aged
Pharmacology. Drug treatments
Recurrence
Skin, nail, hair, dermoskeleton
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Summary:Granulomatous cheilitis (GC) is a chronic edema which frequently affects the upper lip due to granulomatous inflammation. Its etiology is currently unknown. This rare disease is generally accompanied by Melkersson-Rosenthal syndrome (MRS), characterized by scrotal tongue, orofacial edema and facial paralysis. However, it is also known to develop only with orofacial edema. Granulomatous cheilitis is a difficult disease to treat because of recurrences. There are contradictory reports about the results of treatment without surgical intervention and the rates of recurrence. Our case was a 57-year-old female patient who was characterized by orofacial edema only. The edema and erythema had persisted for 1 year before admission. In the present case, application of intralesional corticosteroid treatment as a total of three injections over 3 consecutive months (one injection per month) and the accompanying metronidazole treatment brought about successful results. No recurrence was observed in the follow-up.
ISSN:0954-6634
1471-1753
DOI:10.1080/09546630410015538