Selenium-loaded cellulose film derived from Styela clava tunic accelerates the healing process of cutaneous wounds in streptozotocin-induced diabetic Sprague-Dawley rats

Purpose: Aims of this study is to evaluate the therapeutic effects and toxicity of Se-loaded cellulose film originated from Styela clava tunic (SeSCTF) on cutaneous wounds during diabetic conditions. Materials and methods: Alterations in skin regeneration, angiogenesis and toxicity were examined usi...

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Published in:The Journal of dermatological treatment 2018-08, Vol.29 (6), p.606-616
Main Authors: Song, Sung Hwa, Kim, Ji Eun, Koh, Eun Kyoung, Sung, Ji Eun, Lee, Hyun Ah, Yun, Woo Bin, Hong, Jin Tae, Hwang, Dae Youn
Format: Article
Language:English
Subjects:
angiogenesis
cellulose film
diabetes
selenium
Styela clava tunic
surgical wound
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cited_by cdi_FETCH-LOGICAL-c366t-d78f88c4d194187232d23104a9975b75f81d216905394b3ee2175d27ced6d24f3
cites cdi_FETCH-LOGICAL-c366t-d78f88c4d194187232d23104a9975b75f81d216905394b3ee2175d27ced6d24f3
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container_issue 6
container_start_page 606
container_title The Journal of dermatological treatment
container_volume 29
creator Song, Sung Hwa
Kim, Ji Eun
Koh, Eun Kyoung
Sung, Ji Eun
Lee, Hyun Ah
Yun, Woo Bin
Hong, Jin Tae
Hwang, Dae Youn
description Purpose: Aims of this study is to evaluate the therapeutic effects and toxicity of Se-loaded cellulose film originated from Styela clava tunic (SeSCTF) on cutaneous wounds during diabetic conditions. Materials and methods: Alterations in skin regeneration, angiogenesis and toxicity were examined using streptozotocine (STZ)-induced diabetic Sprague Dawley ® (SD) rats with surgical skin wounds after application of SeSCTF for 12 days. Results: SCTF showed high tensile strength (1.64 MPa), low elongation (28.59%), low water vapor transmission rate (WVTR) and outstanding porous structure. Although SeSCTF application did not induce any significant alterations in glucose concentration or toxicity, wound morphology was rapidly recovered in the SeSCTF treated group relative to the gauze (GZ) and SCTF treated group. Moreover, recovery of re-epithelization, wound contraction and number of blood vessel was observed in SeSCTF treated groups when compared with all other groups. Furthermore, the SeSCTF treated group showed complete recovery of key protein expressions of the downstream signaling pathway of vascular endothelial growth factor (VEGF), angiopoietin-2/1 (Ang-2/1), the signaling pathway of insulin receptors and anti-oxidative status. Conclusions: Overall, the results of this study suggest that SeSCTF accelerates the healing process of cutaneous wounds in STZ-induced diabetic SD rats through stimulation of angiogenesis and the glucose receptor signaling pathway.
doi_str_mv 10.1080/09546634.2018.1425357
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Materials and methods: Alterations in skin regeneration, angiogenesis and toxicity were examined using streptozotocine (STZ)-induced diabetic Sprague Dawley ® (SD) rats with surgical skin wounds after application of SeSCTF for 12 days. Results: SCTF showed high tensile strength (1.64 MPa), low elongation (28.59%), low water vapor transmission rate (WVTR) and outstanding porous structure. Although SeSCTF application did not induce any significant alterations in glucose concentration or toxicity, wound morphology was rapidly recovered in the SeSCTF treated group relative to the gauze (GZ) and SCTF treated group. Moreover, recovery of re-epithelization, wound contraction and number of blood vessel was observed in SeSCTF treated groups when compared with all other groups. Furthermore, the SeSCTF treated group showed complete recovery of key protein expressions of the downstream signaling pathway of vascular endothelial growth factor (VEGF), angiopoietin-2/1 (Ang-2/1), the signaling pathway of insulin receptors and anti-oxidative status. Conclusions: Overall, the results of this study suggest that SeSCTF accelerates the healing process of cutaneous wounds in STZ-induced diabetic SD rats through stimulation of angiogenesis and the glucose receptor signaling pathway.</description><identifier>ISSN: 0954-6634</identifier><identifier>EISSN: 1471-1753</identifier><identifier>DOI: 10.1080/09546634.2018.1425357</identifier><identifier>PMID: 29409374</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>angiogenesis ; cellulose film ; diabetes ; selenium ; Styela clava tunic ; surgical wound</subject><ispartof>The Journal of dermatological treatment, 2018-08, Vol.29 (6), p.606-616</ispartof><rights>2018 Informa UK Limited, trading as Taylor &amp; Francis Group 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-d78f88c4d194187232d23104a9975b75f81d216905394b3ee2175d27ced6d24f3</citedby><cites>FETCH-LOGICAL-c366t-d78f88c4d194187232d23104a9975b75f81d216905394b3ee2175d27ced6d24f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29409374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Sung Hwa</creatorcontrib><creatorcontrib>Kim, Ji Eun</creatorcontrib><creatorcontrib>Koh, Eun Kyoung</creatorcontrib><creatorcontrib>Sung, Ji Eun</creatorcontrib><creatorcontrib>Lee, Hyun Ah</creatorcontrib><creatorcontrib>Yun, Woo Bin</creatorcontrib><creatorcontrib>Hong, Jin Tae</creatorcontrib><creatorcontrib>Hwang, Dae Youn</creatorcontrib><title>Selenium-loaded cellulose film derived from Styela clava tunic accelerates the healing process of cutaneous wounds in streptozotocin-induced diabetic Sprague-Dawley rats</title><title>The Journal of dermatological treatment</title><addtitle>J Dermatolog Treat</addtitle><description>Purpose: Aims of this study is to evaluate the therapeutic effects and toxicity of Se-loaded cellulose film originated from Styela clava tunic (SeSCTF) on cutaneous wounds during diabetic conditions. Materials and methods: Alterations in skin regeneration, angiogenesis and toxicity were examined using streptozotocine (STZ)-induced diabetic Sprague Dawley ® (SD) rats with surgical skin wounds after application of SeSCTF for 12 days. Results: SCTF showed high tensile strength (1.64 MPa), low elongation (28.59%), low water vapor transmission rate (WVTR) and outstanding porous structure. Although SeSCTF application did not induce any significant alterations in glucose concentration or toxicity, wound morphology was rapidly recovered in the SeSCTF treated group relative to the gauze (GZ) and SCTF treated group. Moreover, recovery of re-epithelization, wound contraction and number of blood vessel was observed in SeSCTF treated groups when compared with all other groups. Furthermore, the SeSCTF treated group showed complete recovery of key protein expressions of the downstream signaling pathway of vascular endothelial growth factor (VEGF), angiopoietin-2/1 (Ang-2/1), the signaling pathway of insulin receptors and anti-oxidative status. 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects angiogenesis
cellulose film
diabetes
selenium
Styela clava tunic
surgical wound
title Selenium-loaded cellulose film derived from Styela clava tunic accelerates the healing process of cutaneous wounds in streptozotocin-induced diabetic Sprague-Dawley rats
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