Effects of carbomer 940 hydrogel on burn wounds: an in vitro and in vivo study

Purpose: This study was designed to investigate the applicability of carbomer 940 hydrogel on skin-burn wounds by focusing on its effects on the zone of stasis. Method: Fibroblast cells were used to assess the cytotoxicity of carbomer 940. Wound healing was monitored by laser Doppler flowmetry and h...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2018-08, Vol.29 (6), p.593-599
Main Authors: Hayati, Farzad, Ghamsari, Seyed Mehdi, Dehghan, Mohammad Mehdi, Oryan, Ahmad
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Acrylic Resins - pharmacology
Acrylic Resins - therapeutic use
Administration, Topical
Animals
burn-wound healing
Burns - drug therapy
Carbomer 940
Cell Survival - drug effects
cytotoxicity
Hydrogels - chemistry
Hydrogels - pharmacology
Laser-Doppler Flowmetry
Male
rat
Rats
Rats, Wistar
Skin - drug effects
Skin - pathology
Wound Healing - drug effects
zone of stasis
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Summary:Purpose: This study was designed to investigate the applicability of carbomer 940 hydrogel on skin-burn wounds by focusing on its effects on the zone of stasis. Method: Fibroblast cells were used to assess the cytotoxicity of carbomer 940. Wound healing was monitored by laser Doppler flowmetry and histopathological analysis. Twenty adult male Wistar rats were randomly divided into two groups (N = 10 each). After shaving their dorsum, a 'burn comb' was contacted bilaterally on each side of the spine. Carbomer 940 hydrogel and TegaDerm were used as topical dressing, in the experimental group, while normal saline and TegaDerm were used as the control. The dressing was changed daily and the blood flow was measured until the animals were euthanized. The wound samples were collected at days 3 and 21 for histopathological studies. Cell viability study showed that the hydrogel was non-cytotoxic. Result: Our results revealed that skin blood perfusion in the zone of stasis was elevated at 24 hour post-burning, in the experimental group but not in the control group (p 
ISSN:0954-6634
1471-1753
DOI:10.1080/09546634.2018.1426823