Efficacy and safety of fractional CO 2 laser and tranexamic acid versus microneedling and tranexamic acid in the treatment of infraorbital hyperpigmentation

To compare the efficacy and safety of microneedling and fractional CO laser in combination with tranexamic acid (TA) in the treatment of infra-orbital hyperpigmentation. This split-face clinical trial performed on 30 volunteers. The patients were randomly assigned to treat with fractional CO laser a...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2022-05, Vol.33 (3), p.1391-1396
Main Authors: Ghandehari, Reza, Robati, Reza M, Niknezhad, Nasim, Hajizadeh, Nastaran, Tehranchinia, Zohreh
Format: Article
Language:English
Subjects:
Carbon Dioxide
Humans
Hyperpigmentation - drug therapy
Hyperpigmentation - therapy
Lasers, Gas - adverse effects
Tranexamic Acid - adverse effects
Treatment Outcome
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Summary:To compare the efficacy and safety of microneedling and fractional CO laser in combination with tranexamic acid (TA) in the treatment of infra-orbital hyperpigmentation. This split-face clinical trial performed on 30 volunteers. The patients were randomly assigned to treat with fractional CO laser and microneedling, both combined with TA topically. Three monthly treatment sessions were performed. Two blinded dermatologists evaluated the response after each treatment session and one and three months after the last session. We also asked patients to evaluate their overall satisfaction at the final follow up. Adverse effects have also been documented. Both methods showed significant improvement in all sessions comparing with the baseline state ( value
ISSN:0954-6634
1471-1753
DOI:10.1080/09546634.2020.1819527