Radiation protection in therapy with radiopharmaceuticals

Purpose: Radionuclide therapy (RNT) involves the selective delivery of radiation, emitted from radionuclides to tumors or target organs. The techniques of RNT are increasingly being used for the treatment of various tumors. The purpose of this article is to report on the current state of RNT, to cla...

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Bibliographic Details
Published in:International journal of radiation biology 2019-10, Vol.95 (10), p.1427-1430
Main Author: Hosono, Makoto
Format: Article
Language:English
Subjects:
Carcinogenesis
dosimetry
Humans
Neoplasms - radiotherapy
Neoplasms, Radiation-Induced
Neoplasms, Second Primary - etiology
Radiation Protection - methods
Radiobiology - methods
Radioisotopes - therapeutic use
Radiometry - methods
radionuclide therapy
Radiopharmaceuticals - therapeutic use
Radiotherapy - methods
second primary cancer
Theranostic Nanomedicine
theranostics
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Summary:Purpose: Radionuclide therapy (RNT) involves the selective delivery of radiation, emitted from radionuclides to tumors or target organs. The techniques of RNT are increasingly being used for the treatment of various tumors. The purpose of this article is to report on the current state of RNT, to clarify the issues of radiation protection associated with RNT, and to show future prospects. Results and conclusions: Medical exposure of patients has unique features; application of dose limits is not undertaken, and justification and optimization do apply but in a different way from in other exposures. The expanding use of RNT has raised concern regarding potential carcinogenic and leukemogenic effects and research on second primary cancer after RNT have been developing. RNT combined with imaging and dosimetry and featuring a theranostic approach is undergoing a significant expansion, and such dosimetry-based treatment planning leads to individualization, or personalization, which is likely to improve the effectiveness and safety of patient management in RNT.
ISSN:0955-3002
1362-3095
DOI:10.1080/09553002.2018.1516910