Chromosome aberrations, micronucleus frequency, and catalase concentration in a population chronically exposed to high levels of radon

To deepen our knowledge on the effects of high levels of indoor radon exposure, we assessed the frequencies of unstable and stable chromosome aberrations and micronucleus (MN), as well as the concentration of an endogenous antioxidant (catalase, CAT), in blood samples of individuals chronically expo...

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Published in:International journal of radiation biology 2023-08, Vol.99 (8), p.1188-1203
Main Authors: Ramadhani, Dwi, Purnami, Sofiati, Tetriana, Devita, Sugoro, Irawan, Suvifan, Viria Agesti, Rahadjeng, Nastiti, Wanandi, Septelia Inawati, Wibowo, Heri, Kashiwakura, Ikuo, Miura, Tomisato, Syaifudin, Mukh
Format: Article
Language:English
Subjects:
Adaptation, Physiological - radiation effects
Adolescent
Adult
Aged
Antioxidant
catalase
Catalase - blood
Chromosome Aberrations - radiation effects
Chromosome Aberrations - statistics & numerical data
cytogenetic
Female
Humans
Indonesia
Male
Mamuju
Micronuclei, Chromosome-Defective - statistics & numerical data
micronucleus
Middle Aged
Radiation Dosage
radon
Radon - analysis
Radon - toxicity
Young Adult
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Summary:To deepen our knowledge on the effects of high levels of indoor radon exposure, we assessed the frequencies of unstable and stable chromosome aberrations and micronucleus (MN), as well as the concentration of an endogenous antioxidant (catalase, CAT), in blood samples of individuals chronically exposed to high indoor radon concentrations in Indonesia (Tande-Tande sub-village, Mamuju, West Sulawesi). Moreover, we also investigated the occurrence of a radio-adaptive response (RAR) in Tande-Tande sub-village inhabitants using the G 2 MN assay. The frequencies of dicentric (DC), acentric (AF), ring (R), and translocation (Tr) chromosomes in Tande-Tande inhabitants were compared to those in people living in a reference area with low levels of indoor radon levels (Topoyo village, Indonesia). The number of MN per 1000 binucleated cells (BNC) and CAT concentration per total protein was quantified and compared between groups. Lastly, we irradiated (2 Gy) phytohemagglutinin-stimulated samples in vitro and measured the frequency of MN to verify the occurrence of a RAR in Tande-Tande sub-village inhabitants. The frequencies of DC, AF, and Tr did not differ between Tande-Tande inhabitants and control subjects (p = 0.350, 0.521, 0.597). The frequency of MN in Tande-Tande inhabitants was significantly lower than that in the control group (p = 0.006). Similarly, CAT concentration in Tande-Tande inhabitants was also significantly lower than that in the control population (p 
ISSN:0955-3002
1362-3095
DOI:10.1080/09553002.2022.2110314