Association between ALOX15 gene polymorphism and brick-tea type skeletal fluorosis in Tibetans, Kazaks and Han, China

To evaluate the association between ALOX15 gene polymorphism and skeletal fluorosis (SF), a case-control study was conducted. A total of 1023 individuals, including 308 Tibetans, 290 Kazaks and 425 Han, were enrolled in this study, in which cases and controls were 278 and 745, respectively. SF was d...

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Bibliographic Details
Published in:International journal of environmental health research 2021-06, Vol.31 (4), p.421-432
Main Authors: Chu, Yanru, Liu, Yang, Guo, Ning, Lou, Qun, Wang, Limei, Huang, Wei, Wu, Liaowei, Wang, Jian, Zhang, Meichen, Yin, Fanshuo, Gao, Yanhui, Yang, Yanmei
Format: Article
Language:English
Subjects:
Absorptiometry
Adolescent
Adult
Aged
Aged, 80 and over
ALOX15
Arachidonate 15-Lipoxygenase - genetics
Bone Diseases, Metabolic - epidemiology
Bone Diseases, Metabolic - genetics
Brick-tea type fluorosis
Case-Control Studies
China - epidemiology
China - ethnology
Construction materials
Cross-Sectional Studies
Female
Fluoridation
Fluorides
Fluorosis
Gene polymorphism
Genotypes
Haplotypes
Humans
Kazakhstan - ethnology
Male
Middle Aged
Nucleotides
Polymorphism
Polymorphism, Genetic
Risk
Single-nucleotide polymorphism
skeletal fluorosis
Tea
Tibet - ethnology
Young Adult
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Summary:To evaluate the association between ALOX15 gene polymorphism and skeletal fluorosis (SF), a case-control study was conducted. A total of 1023 individuals, including 308 Tibetans, 290 Kazaks and 425 Han, were enrolled in this study, in which cases and controls were 278 and 745, respectively. SF was diagnosed by X-ray absorptiometry. SNPs were genotyped using the Sequenom Mass ARRAY system. The genotypes of ALOX15 rs7220870, rs2664593 and rs1107852 were not associated with the risk of SF. After reconstructing the haplotype of rs7220870 and rs11078528, the risk effect of haplotype CA was found in Han participants aged ≤45 years or with moderate fluoride intake. Diplotype of CC/CC had a protective effect on SF risk in Han participants; whereas, CA/CC diplotype showed a risk effect on SF risk in participants aged ≥65; Our results provide the first evidence of an association between ALOX15 gene polymorphism and SF risk in Han participants. Abbreviation: SF: Skeletal fluorosis; SNP: Single Nucleotide polymorphism
ISSN:0960-3123
1369-1619
DOI:10.1080/09603123.2019.1666972