Static electric field exposure decreases white blood cell count in peripheral blood through activating hypothalamic-pituitary-adrenal axis

With the development of ultra-high-voltage (UHV) direct-current (DC) transmission, the health risk from the static electric field (SEF) generated by UHV DC transmission lines has drawn public attention. To investigate the effect of SEF exposure on white blood cell (WBC) count, mice were exposed to 5...

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Bibliographic Details
Published in:International journal of environmental health research 2024, Vol.34 (1), p.305-315
Main Authors: Wu, Jiahong, Dong, Li, Xiang, Junli, Di, Guoqing
Format: Article
Language:English
Subjects:
Adrenocorticotropic hormone
Apoptosis
Cell number
Circuits
Corticosterone
Corticotropin-releasing hormone
Electric fields
Exposure
Glucocorticoid receptors
Glucocorticoids
Health risks
HPA axis
Hypothalamic-pituitary-adrenal axis
Hypothalamus
immune function
Leukocyte migration
Leukocytes
Lymphocytes
Negative feedback
Neural networks
Peripheral blood
Pituitary
Serum levels
static electric field
Transmission lines
Ultra-high-voltage direct-current transmission
white blood cell
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Summary:With the development of ultra-high-voltage (UHV) direct-current (DC) transmission, the health risk from the static electric field (SEF) generated by UHV DC transmission lines has drawn public attention. To investigate the effect of SEF exposure on white blood cell (WBC) count, mice were exposed to 56.3 kV/m SEF. Results revealed that total WBC count and lymphocyte count significantly decreased and serum levels of corticotropin-releasing hormone, adrenocorticotropic hormone and corticosterone (CORT) significantly increased after the exposure of 7d and 14d. All indices above recovered after the exposure of 21d. Analysis showed that the exposure of 7d and 14d could activate hypothalamic-pituitary-adrenal (HPA) axis. The increased CORT could bind to the glucocorticoid receptor (GR) in lymphocytes, and then promote the migration and apoptosis of lymphocytes. After the exposure of 21d, the magnitude of HPA axis activation declined through CORT-mediated negative feedback and the regulation of stress-related neural circuitry, so WBC count recovered.
ISSN:0960-3123
1369-1619
DOI:10.1080/09603123.2022.2148636