Impact of phthalate metabolites on vitamin D levels and subclinical inflammation: national health and nutrition examination survey, 2013-2018

This study explores the association between phthalates and total vitamin D levels and the link between phthalates exposure and subclinical inflammation using monocyte percentage to high-density lipoprotein cholesterol ratio (MHR), utilizing three National Health and Nutrition Examination Survey (NHA...

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Bibliographic Details
Published in:International journal of environmental health research 2024-09, Vol.34 (9), p.3136-3146
Main Authors: Mahmoud, Elhassan, Elsayed, Abdalla Moustafa, Kaleem, Muhammad Zain, Alkorbi, Hamad A., Elshoeibi, Amgad M., Chivese, Tawanda, Zughaier, Susu M.
Format: Article
Language:English
Subjects:
25(OH)D
Adolescent
Adult
Aged
Calciferol
Cholesterol
Cross-Sectional Studies
Dioctyl phthalate
Environmental Exposure
Environmental Pollutants - blood
Environmental Pollutants - urine
Female
High density lipoprotein
Humans
Inflammation
Inflammation - blood
Inflammation - chemically induced
Male
Metabolites
MHR
Middle Aged
Monocytes
Nutrition Surveys
Phthalate esters
Phthalates
Phthalic Acids - urine
plasticizers
Surveys
United States - epidemiology
Vitamin D
Vitamin D - blood
Young Adult
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Summary:This study explores the association between phthalates and total vitamin D levels and the link between phthalates exposure and subclinical inflammation using monocyte percentage to high-density lipoprotein cholesterol ratio (MHR), utilizing three National Health and Nutrition Examination Survey (NHANES) survey cycles 2013-2018. This study is cross-sectional, utilizing one-time urine samples from randomly selected NHANES participants to assess phthalate metabolites. An inverse association between vitamin D and all Di(2-ethylhexyl) phthalate (DEHP) metabolites was found. The molar sum of DEHP metabolites was inversely associated with vitamin D (β −2.329; 95% CI −3.937,−0.720). An inverse association was observed between monocarboxynonyl phthalate and vitamin D (β −0.0278; 95% CI −0.0527,−0.00298). A similar relationship was found between monocarboxyoctyl phthalate and vitamin D (β −0.0160; 95% CI −0.0242,−0.00775). There was no association between phthalate metabolites and MHR. Stratified analysis showed that the association between phthalate metabolites and MHR may vary according to vitamin D status.
ISSN:0960-3123
1369-1619
1369-1619
DOI:10.1080/09603123.2023.2299216