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Small, qualitative changes in fatty acid intake decrease plasma low-density lipoprotein-cholesterol levels in mildly hypercholesterolemic outpatients on their usual high-fat diets
Objective The diet is the first step in managing hypercholesterolemia. The objective of the present study is to assess whether moderate changes in dietary fatty acids improve plasma lipid parameters in mildly hypercholesterolemic outpatients. Methods Using a randomized double-blind study, 121 outpat...
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| Published in: | International journal of food sciences and nutrition 2009-01, Vol.60 (s7), p.151-163 |
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| container_end_page | 163 |
| container_issue | s7 |
| container_start_page | 151 |
| container_title | International journal of food sciences and nutrition |
| container_volume | 60 |
| creator | Lecerf, Jean-Michel Luc, Gérald Marécaux, Nadine Bal, Sylvie Bonte, Jean-Paul Lacroix, Brigitte Cayzeele, Amélie |
| description | Objective The diet is the first step in managing hypercholesterolemia. The objective of the present study is to assess whether moderate changes in dietary fatty acids improve plasma lipid parameters in mildly hypercholesterolemic outpatients.
Methods Using a randomized double-blind study, 121 outpatients within two groups received an isocaloric amount of unsaturated margarine or butter. Clinical and anthropometric measurements and a 3-day food record were made. Chi-square and Fisher's tests were used to compare qualitative variables and the general linear procedure was used to compare the groups. Additional analyses were performed after adjustment.
Results There was a significant difference (P |
| doi_str_mv | 10.1080/09637480902758727 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_09637480902758727</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733854595</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-d82ba55fd583ec2ed079553be397645f382c07b63a6e1f8fff500fcd51aabb8e3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSMEoqXwAGyQxYYNATuOY0ewQRV_UiUWwDqa2OPGxYlT22l1n4sXxOVeqfwIVqPRfOfojE5VPWb0BaOKvqR9x2WraE8bKZRs5J3qmLWdqHkr1d3q-OZeF6A7qh6kdEEpZULK-9UR67lifc-Oq--fZ_D-ObncwLsM2V0h0RMs55iIW4iFnHcEtDNly_ANiUEdERKS1UOagfhwXRtckiucd2tYY8jollpPwWPKGIMnHq_Q__SbnTd-R6bdivEXAmenSdjyWgLgkhMJC8kTuki2VIKRyZ1PdclCjMOcHlb3LPiEjw7zpPr67u2X0w_12af3H0_fnNWaqzbXRjUjCGGNUBx1g4bKXgg-Iu9l1wrLVaOpHDsOHTKrrLWCUquNYADjqJCfVM_2vuWny61EHWaXNHoPC4YtDZJzJVrRi0I-_YO8CFtcSrihYV2r-ralBWJ7SMeQUkQ7rNHNEHcDo8NNn8NffRbNk4PxNs5obhWHAgvweg-4xYY4w3WI3gwZdj5EG2HRLg38f_6vfpNPCD5PGiLefvBv9Q93jMYX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216489440</pqid></control><display><type>article</type><title>Small, qualitative changes in fatty acid intake decrease plasma low-density lipoprotein-cholesterol levels in mildly hypercholesterolemic outpatients on their usual high-fat diets</title><source>Taylor and Francis Science and Technology Collection</source><source>EBSCOhost SPORTDiscus - Ebooks</source><creator>Lecerf, Jean-Michel ; Luc, Gérald ; Marécaux, Nadine ; Bal, Sylvie ; Bonte, Jean-Paul ; Lacroix, Brigitte ; Cayzeele, Amélie</creator><creatorcontrib>Lecerf, Jean-Michel ; Luc, Gérald ; Marécaux, Nadine ; Bal, Sylvie ; Bonte, Jean-Paul ; Lacroix, Brigitte ; Cayzeele, Amélie</creatorcontrib><description>Objective The diet is the first step in managing hypercholesterolemia. The objective of the present study is to assess whether moderate changes in dietary fatty acids improve plasma lipid parameters in mildly hypercholesterolemic outpatients.
Methods Using a randomized double-blind study, 121 outpatients within two groups received an isocaloric amount of unsaturated margarine or butter. Clinical and anthropometric measurements and a 3-day food record were made. Chi-square and Fisher's tests were used to compare qualitative variables and the general linear procedure was used to compare the groups. Additional analyses were performed after adjustment.
Results There was a significant difference (P <0.03) in low-density lipoprotein-cholesterol levels between the groups. Total cholesterol, low-density lipoprotein-cholesterol, non-high-density lipoprotein-cholesterol and apolipoprotein B values decreased in the unsaturated group in comparison with the saturated group. Low-density lipoprotein-cholesterol changes were correlated with the variation in polyunsaturated fatty acid intake and with plasma phospholipid linoleic acid levels.
Conclusion A small change in saturated by polyunsaturated fatty acid intake may improve plasma lipid parameters in mildly hypercholesterolemic subjects.</description><identifier>ISSN: 0963-7486</identifier><identifier>EISSN: 1465-3478</identifier><identifier>DOI: 10.1080/09637480902758727</identifier><identifier>PMID: 19381991</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Aged ; Atherosclerosis - prevention & control ; Butter - analysis ; cardiovascular risk ; Cholesterol, LDL - blood ; Comparative analysis ; Correlation analysis ; Diet ; Diet Records ; Diet, Atherogenic ; Dietary Fats, Unsaturated - administration & dosage ; Double-Blind Method ; Early Diagnosis ; Fatty acids ; Female ; Food science ; Health Promotion ; Humans ; hypercholesterolemia ; Hypercholesterolemia - blood ; Hypercholesterolemia - diet therapy ; Lipids ; Low density lipoprotein ; Low-density lipoprotein cholesterol ; Male ; margarine ; Margarine - analysis ; Middle Aged ; Outpatients ; Patient Compliance ; Plasma ; Risk Factors ; Statistics as Topic</subject><ispartof>International journal of food sciences and nutrition, 2009-01, Vol.60 (s7), p.151-163</ispartof><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><rights>Copyright Taylor & Francis Ltd. Sep 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c384t-d82ba55fd583ec2ed079553be397645f382c07b63a6e1f8fff500fcd51aabb8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19381991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lecerf, Jean-Michel</creatorcontrib><creatorcontrib>Luc, Gérald</creatorcontrib><creatorcontrib>Marécaux, Nadine</creatorcontrib><creatorcontrib>Bal, Sylvie</creatorcontrib><creatorcontrib>Bonte, Jean-Paul</creatorcontrib><creatorcontrib>Lacroix, Brigitte</creatorcontrib><creatorcontrib>Cayzeele, Amélie</creatorcontrib><title>Small, qualitative changes in fatty acid intake decrease plasma low-density lipoprotein-cholesterol levels in mildly hypercholesterolemic outpatients on their usual high-fat diets</title><title>International journal of food sciences and nutrition</title><addtitle>Int J Food Sci Nutr</addtitle><description>Objective The diet is the first step in managing hypercholesterolemia. The objective of the present study is to assess whether moderate changes in dietary fatty acids improve plasma lipid parameters in mildly hypercholesterolemic outpatients.
Methods Using a randomized double-blind study, 121 outpatients within two groups received an isocaloric amount of unsaturated margarine or butter. Clinical and anthropometric measurements and a 3-day food record were made. Chi-square and Fisher's tests were used to compare qualitative variables and the general linear procedure was used to compare the groups. Additional analyses were performed after adjustment.
Results There was a significant difference (P <0.03) in low-density lipoprotein-cholesterol levels between the groups. Total cholesterol, low-density lipoprotein-cholesterol, non-high-density lipoprotein-cholesterol and apolipoprotein B values decreased in the unsaturated group in comparison with the saturated group. Low-density lipoprotein-cholesterol changes were correlated with the variation in polyunsaturated fatty acid intake and with plasma phospholipid linoleic acid levels.
Conclusion A small change in saturated by polyunsaturated fatty acid intake may improve plasma lipid parameters in mildly hypercholesterolemic subjects.</description><subject>Adult</subject><subject>Aged</subject><subject>Atherosclerosis - prevention & control</subject><subject>Butter - analysis</subject><subject>cardiovascular risk</subject><subject>Cholesterol, LDL - blood</subject><subject>Comparative analysis</subject><subject>Correlation analysis</subject><subject>Diet</subject><subject>Diet Records</subject><subject>Diet, Atherogenic</subject><subject>Dietary Fats, Unsaturated - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Early Diagnosis</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Food science</subject><subject>Health Promotion</subject><subject>Humans</subject><subject>hypercholesterolemia</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - diet therapy</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Low-density lipoprotein cholesterol</subject><subject>Male</subject><subject>margarine</subject><subject>Margarine - analysis</subject><subject>Middle Aged</subject><subject>Outpatients</subject><subject>Patient Compliance</subject><subject>Plasma</subject><subject>Risk Factors</subject><subject>Statistics as Topic</subject><issn>0963-7486</issn><issn>1465-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhSMEoqXwAGyQxYYNATuOY0ewQRV_UiUWwDqa2OPGxYlT22l1n4sXxOVeqfwIVqPRfOfojE5VPWb0BaOKvqR9x2WraE8bKZRs5J3qmLWdqHkr1d3q-OZeF6A7qh6kdEEpZULK-9UR67lifc-Oq--fZ_D-ObncwLsM2V0h0RMs55iIW4iFnHcEtDNly_ANiUEdERKS1UOagfhwXRtckiucd2tYY8jollpPwWPKGIMnHq_Q__SbnTd-R6bdivEXAmenSdjyWgLgkhMJC8kTuki2VIKRyZ1PdclCjMOcHlb3LPiEjw7zpPr67u2X0w_12af3H0_fnNWaqzbXRjUjCGGNUBx1g4bKXgg-Iu9l1wrLVaOpHDsOHTKrrLWCUquNYADjqJCfVM_2vuWny61EHWaXNHoPC4YtDZJzJVrRi0I-_YO8CFtcSrihYV2r-ralBWJ7SMeQUkQ7rNHNEHcDo8NNn8NffRbNk4PxNs5obhWHAgvweg-4xYY4w3WI3gwZdj5EG2HRLg38f_6vfpNPCD5PGiLefvBv9Q93jMYX</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Lecerf, Jean-Michel</creator><creator>Luc, Gérald</creator><creator>Marécaux, Nadine</creator><creator>Bal, Sylvie</creator><creator>Bonte, Jean-Paul</creator><creator>Lacroix, Brigitte</creator><creator>Cayzeele, Amélie</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>Small, qualitative changes in fatty acid intake decrease plasma low-density lipoprotein-cholesterol levels in mildly hypercholesterolemic outpatients on their usual high-fat diets</title><author>Lecerf, Jean-Michel ; Luc, Gérald ; Marécaux, Nadine ; Bal, Sylvie ; Bonte, Jean-Paul ; Lacroix, Brigitte ; Cayzeele, Amélie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-d82ba55fd583ec2ed079553be397645f382c07b63a6e1f8fff500fcd51aabb8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atherosclerosis - prevention & control</topic><topic>Butter - analysis</topic><topic>cardiovascular risk</topic><topic>Cholesterol, LDL - blood</topic><topic>Comparative analysis</topic><topic>Correlation analysis</topic><topic>Diet</topic><topic>Diet Records</topic><topic>Diet, Atherogenic</topic><topic>Dietary Fats, Unsaturated - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Early Diagnosis</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Food science</topic><topic>Health Promotion</topic><topic>Humans</topic><topic>hypercholesterolemia</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - diet therapy</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Low-density lipoprotein cholesterol</topic><topic>Male</topic><topic>margarine</topic><topic>Margarine - analysis</topic><topic>Middle Aged</topic><topic>Outpatients</topic><topic>Patient Compliance</topic><topic>Plasma</topic><topic>Risk Factors</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lecerf, Jean-Michel</creatorcontrib><creatorcontrib>Luc, Gérald</creatorcontrib><creatorcontrib>Marécaux, Nadine</creatorcontrib><creatorcontrib>Bal, Sylvie</creatorcontrib><creatorcontrib>Bonte, Jean-Paul</creatorcontrib><creatorcontrib>Lacroix, Brigitte</creatorcontrib><creatorcontrib>Cayzeele, Amélie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of food sciences and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lecerf, Jean-Michel</au><au>Luc, Gérald</au><au>Marécaux, Nadine</au><au>Bal, Sylvie</au><au>Bonte, Jean-Paul</au><au>Lacroix, Brigitte</au><au>Cayzeele, Amélie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small, qualitative changes in fatty acid intake decrease plasma low-density lipoprotein-cholesterol levels in mildly hypercholesterolemic outpatients on their usual high-fat diets</atitle><jtitle>International journal of food sciences and nutrition</jtitle><addtitle>Int J Food Sci Nutr</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>60</volume><issue>s7</issue><spage>151</spage><epage>163</epage><pages>151-163</pages><issn>0963-7486</issn><eissn>1465-3478</eissn><abstract>Objective The diet is the first step in managing hypercholesterolemia. The objective of the present study is to assess whether moderate changes in dietary fatty acids improve plasma lipid parameters in mildly hypercholesterolemic outpatients.
Methods Using a randomized double-blind study, 121 outpatients within two groups received an isocaloric amount of unsaturated margarine or butter. Clinical and anthropometric measurements and a 3-day food record were made. Chi-square and Fisher's tests were used to compare qualitative variables and the general linear procedure was used to compare the groups. Additional analyses were performed after adjustment.
Results There was a significant difference (P <0.03) in low-density lipoprotein-cholesterol levels between the groups. Total cholesterol, low-density lipoprotein-cholesterol, non-high-density lipoprotein-cholesterol and apolipoprotein B values decreased in the unsaturated group in comparison with the saturated group. Low-density lipoprotein-cholesterol changes were correlated with the variation in polyunsaturated fatty acid intake and with plasma phospholipid linoleic acid levels.
Conclusion A small change in saturated by polyunsaturated fatty acid intake may improve plasma lipid parameters in mildly hypercholesterolemic subjects.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>19381991</pmid><doi>10.1080/09637480902758727</doi><tpages>13</tpages></addata></record> |
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| identifier | ISSN: 0963-7486 |
| ispartof | International journal of food sciences and nutrition, 2009-01, Vol.60 (s7), p.151-163 |
| issn | 0963-7486 1465-3478 |
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| source | Taylor and Francis Science and Technology Collection; EBSCOhost SPORTDiscus - Ebooks |
| subjects | Adult Aged Atherosclerosis - prevention & control Butter - analysis cardiovascular risk Cholesterol, LDL - blood Comparative analysis Correlation analysis Diet Diet Records Diet, Atherogenic Dietary Fats, Unsaturated - administration & dosage Double-Blind Method Early Diagnosis Fatty acids Female Food science Health Promotion Humans hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - diet therapy Lipids Low density lipoprotein Low-density lipoprotein cholesterol Male margarine Margarine - analysis Middle Aged Outpatients Patient Compliance Plasma Risk Factors Statistics as Topic |
| title | Small, qualitative changes in fatty acid intake decrease plasma low-density lipoprotein-cholesterol levels in mildly hypercholesterolemic outpatients on their usual high-fat diets |
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