Incomplete metabolism of phytoestrogens by gut microbiota from children under the age of three

Phytoestrogens are plant-derived polyphenols with structural and functional similarities to mammalian oestrogens. The aim of this work was to study the metabolism of phytoestrogens by children's intestinal microbiota and to compare it with previous results in adults. Faecal samples of 24 health...

Full description

Saved in:
Bibliographic Details
Published in:International journal of food sciences and nutrition 2018-05, Vol.69 (3), p.334-343
Main Authors: Gaya, Pilar, Sánchez-Jiménez, Abel, Peirotén, Ángela, Medina, Margarita, Landete, José Maria
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - metabolism
Adult
Adults
Butylene Glycols - metabolism
Case-Control Studies
Child, Preschool
Children
Children & youth
Coumarins - metabolism
Digestive system
ellagitannins
Equol - metabolism
Estrogens
Feces - microbiology
Female
Fermentation
Food science
Furans - metabolism
Gastrointestinal Microbiome
Gastrointestinal tract
Humans
Hydrolyzable Tannins - metabolism
Infant
Intestinal microflora
Intestine
Isoflavones
Isoflavones - metabolism
Lignans
Lignans - metabolism
Male
Metabolism
Metabolites
microbial metabolism
Microbiota
Microorganisms
Phytoestrogens
Phytoestrogens - metabolism
Plants
Polyphenols
Polyphenols - metabolism
Structure-function relationships
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phytoestrogens are plant-derived polyphenols with structural and functional similarities to mammalian oestrogens. The aim of this work was to study the metabolism of phytoestrogens by children's intestinal microbiota and to compare it with previous results in adults. Faecal samples of 24 healthy children were subjected to phytoestrogen fermentation assay. Only one child produced equol, while O-desmethylangolensin was found in all. Urolithin production was detected in 14 children and enterolactone in 10. Further comparison with the metabolism of phytoestrogens by adult intestinal microbiota reflected that glycitein, dihydrogenistein, urolithins D and E, enterolactone, secoisolariciresinol and arctigenin were the most important metabolites differentiating between adult and child microbial gut metabolism. Although the child intestinal microbiota showed the ability to metabolise isoflavones, ellagitannins and lignans to a certain extent, it generally showed a reduced metabolism of phytoestrogens, with a lack of 5-hydroxy equol and enterodiol, and less urolithins and enterolactone producers.
ISSN:0963-7486
1465-3478
DOI:10.1080/09637486.2017.1353955