Serum leptin and homeostasis model assessment-IR as novel predictors of early liver fibrosis in chronic hepatitis B virus infection

Background: The relationship between hepatitis B virus (HBV) infection, leptin and insulin resistance remains unclear. We hypothesised links between serum leptin and insulin resistance in non-diabetic patients with chronic viral hepatitis B infection and their relation to liver fibrosis. Methods: We...

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Published in:British journal of biomedical science 2018-10, Vol.75 (4), p.192-196
Main Authors: Mousa, N, Abdel-Razik, A, Sheta, T, Shabana, W, Zakaria, S, Awad, M, Abd Elsalam, M, El-Wakeel, N, Elkashef, W, Effat, N, Elgamal, A, Deiab, AG, Eldars, W
Format: Article
Language:English
Subjects:
Chronic infection
Diabetes
Diabetes mellitus
Disease resistance
Enzyme-linked immunosorbent assay
Fasting
Fibrosis
Glucose
Hepatitis
Hepatitis B
hepatitis B virus
Homeostasis
homeostasis model assessment-IR
Infections
Insulin
Insulin resistance
Leptin
Liver
liver fibrosis
Peptides
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Summary:Background: The relationship between hepatitis B virus (HBV) infection, leptin and insulin resistance remains unclear. We hypothesised links between serum leptin and insulin resistance in non-diabetic patients with chronic viral hepatitis B infection and their relation to liver fibrosis. Methods: We recruited 190 untreated patients with chronic HBV infection and 72 healthy controls. Serum leptin, fasting glucose, insulin, liver function tests (LFTs), C-peptide and Homeostasis model assessment-IR (HOMA-IR) were measured/calculated by ELISA and standard techniques. Results: Serum leptin, C-peptide (both P 
ISSN:0967-4845
2474-0896
DOI:10.1080/09674845.2018.1505187