Cytotoxic Properties of Selected Sesquiterpene Alcohols on Human Cervix Carcinoma Cell Lines

The sesquiterpene alcohols cis-nerolidol, α-bisabolol, cedrol, patchoulol, and santalol were screened for cytotoxicity and cytoproliferative activity on HeLa cell using Cytotoxicity Detection Kit (LDH) and the Cell Proliferation Reagent WST-1, respectively. Actinomycin D and curcumin as well as the...

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Bibliographic Details
Published in:Journal of essential oil-bearing plants (Dehra Dun) 2011, Vol.14 (3), p.316-319
Main Authors: Boris, Ryabchenko, Elena, Tulupova, Erich, Schmidt, Walter, Jäger, Gerhard, Buchbauer, Leopold, Jirovetz
Format: Article
Language:English
Subjects:
actinomycin D
alcohols
alpha-bisabolol
carcinoma
cell proliferation
cell viability
cervix
cis-nerolidol
curcumin
cytotoxicity
HeLa cell line
humans
salicylic acid
sesquiterpene alcohols
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Summary:The sesquiterpene alcohols cis-nerolidol, α-bisabolol, cedrol, patchoulol, and santalol were screened for cytotoxicity and cytoproliferative activity on HeLa cell using Cytotoxicity Detection Kit (LDH) and the Cell Proliferation Reagent WST-1, respectively. Actinomycin D and curcumin as well as the plant acids geranic and salicylic acid were used as reference samples, all known for their cytotoxic properties. Among the sesquiterpene alcohols studied, cis-nerolidol possessed the strongest cytotoxic properties (16.5 μM ± 6.7). Low cytotoxicity and influence on HeLa cell viability was demonstrated for geranic and especially salicylic acid.
ISSN:0976-5026
0972-060X
0976-5026
DOI:10.1080/0972060X.2011.10643940