Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition

Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composit...

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Bibliographic Details
Published in:Isotopes in environmental and health studies 2017-08, Vol.53 (4), p.344-355
Main Authors: Fabiansen, Christian, Yaméogo, Charles W., Devi, Sarita, Friis, Henrik, Kurpad, Anura, Wells, Jonathan C.
Format: Article
Language:English
Subjects:
Acute Disease
Adipose Tissue - metabolism
Balancing
Body Composition
Body Water - metabolism
Children
Deuterium
deuterium dilution
Deuterium Oxide - administration & dosage
Deuterium Oxide - pharmacokinetics
Dilution
equilibration time
Feasibility studies
Humans
Infant
Infants
Intervention
Malnutrition
Malnutrition - diagnosis
Pilot Projects
Radioisotope Dilution Technique
Saliva
Saliva - metabolism
saliva sampling
Severity of Illness Index
Spectroscopy, Fourier Transform Infrared
Studies
tracer technique
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Summary:Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.
ISSN:1025-6016
1477-2639
DOI:10.1080/10256016.2017.1295043