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Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition
Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composit...
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| Published in: | Isotopes in environmental and health studies 2017-08, Vol.53 (4), p.344-355 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c441t-77adb59b04da57c139642bdcb034263c25f678a5489c3172194d4c6546c278013 |
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| cites | cdi_FETCH-LOGICAL-c441t-77adb59b04da57c139642bdcb034263c25f678a5489c3172194d4c6546c278013 |
| container_end_page | 355 |
| container_issue | 4 |
| container_start_page | 344 |
| container_title | Isotopes in environmental and health studies |
| container_volume | 53 |
| creator | Fabiansen, Christian Yaméogo, Charles W. Devi, Sarita Friis, Henrik Kurpad, Anura Wells, Jonathan C. |
| description | Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques. |
| doi_str_mv | 10.1080/10256016.2017.1295043 |
| format | article |
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In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. 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In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.</description><subject>Acute Disease</subject><subject>Adipose Tissue - metabolism</subject><subject>Balancing</subject><subject>Body Composition</subject><subject>Body Water - metabolism</subject><subject>Children</subject><subject>Deuterium</subject><subject>deuterium dilution</subject><subject>Deuterium Oxide - administration & dosage</subject><subject>Deuterium Oxide - pharmacokinetics</subject><subject>Dilution</subject><subject>equilibration time</subject><subject>Feasibility studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Intervention</subject><subject>Malnutrition</subject><subject>Malnutrition - diagnosis</subject><subject>Pilot Projects</subject><subject>Radioisotope Dilution Technique</subject><subject>Saliva</subject><subject>Saliva - metabolism</subject><subject>saliva sampling</subject><subject>Severity of Illness Index</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Studies</subject><subject>tracer technique</subject><issn>1025-6016</issn><issn>1477-2639</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kcluFDEQhlsIRELgEUCWuHDpwbu7OYHCKkXiAmfLbbszjrwMXhLNK_DUeDITDhw42ZK_-qvK3zC8RHCD4ATfIogZh4hvMERig_DMICWPhnNEhRgxJ_Pjfu_MeIDOhmel3ECICJunp8MZnrDggqDz4fdH26rNrgVgnG_VpQiq1dvofjUL1pTBkswe6BR2qbj7Z1WKLSXYWN-BbEvyty5eg2DrNpnk07XTygNXSrMFuAj01nmTbQR3rm5BSMZmVS1QuvcFQfnYar4Pfj48WZUv9sXpvBh-fv704_LrePX9y7fLD1ejphTVUQhlFjYvkBrFhEZk5hQvRi-Q0L63xmzlYlKMTrMmSGA0U0M1Z5RrLKb-BRfDm2PuLqe-ZKkyuKKt9yra1IpEk-B05pCzjr7-B71JLcc-nUQzJoRSQXGn2JHSOZWS7Sp32QWV9xJBeZAlH2TJgyx5ktXrXp3S2xKs-Vv1YKcD74-Ai91EUHcpeyOr2vuU16yidkWS__f4Az6MpZg</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Fabiansen, Christian</creator><creator>Yaméogo, Charles W.</creator><creator>Devi, Sarita</creator><creator>Friis, Henrik</creator><creator>Kurpad, Anura</creator><creator>Wells, Jonathan C.</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8344-6897</orcidid><orcidid>https://orcid.org/0000-0002-2848-2940</orcidid><orcidid>https://orcid.org/0000-0002-5333-8246</orcidid><orcidid>https://orcid.org/0000-0003-0411-8025</orcidid><orcidid>https://orcid.org/0000-0002-1987-781X</orcidid><orcidid>https://orcid.org/0000-0001-7998-2438</orcidid></search><sort><creationdate>201708</creationdate><title>Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition</title><author>Fabiansen, Christian ; Yaméogo, Charles W. ; Devi, Sarita ; Friis, Henrik ; Kurpad, Anura ; Wells, Jonathan C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-77adb59b04da57c139642bdcb034263c25f678a5489c3172194d4c6546c278013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute Disease</topic><topic>Adipose Tissue - metabolism</topic><topic>Balancing</topic><topic>Body Composition</topic><topic>Body Water - metabolism</topic><topic>Children</topic><topic>Deuterium</topic><topic>deuterium dilution</topic><topic>Deuterium Oxide - administration & dosage</topic><topic>Deuterium Oxide - pharmacokinetics</topic><topic>Dilution</topic><topic>equilibration time</topic><topic>Feasibility studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Intervention</topic><topic>Malnutrition</topic><topic>Malnutrition - diagnosis</topic><topic>Pilot Projects</topic><topic>Radioisotope Dilution Technique</topic><topic>Saliva</topic><topic>Saliva - metabolism</topic><topic>saliva sampling</topic><topic>Severity of Illness Index</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Studies</topic><topic>tracer technique</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fabiansen, Christian</creatorcontrib><creatorcontrib>Yaméogo, Charles W.</creatorcontrib><creatorcontrib>Devi, Sarita</creatorcontrib><creatorcontrib>Friis, Henrik</creatorcontrib><creatorcontrib>Kurpad, Anura</creatorcontrib><creatorcontrib>Wells, Jonathan C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Isotopes in environmental and health studies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fabiansen, Christian</au><au>Yaméogo, Charles W.</au><au>Devi, Sarita</au><au>Friis, Henrik</au><au>Kurpad, Anura</au><au>Wells, Jonathan C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition</atitle><jtitle>Isotopes in environmental and health studies</jtitle><addtitle>Isotopes Environ Health Stud</addtitle><date>2017-08</date><risdate>2017</risdate><volume>53</volume><issue>4</issue><spage>344</spage><epage>355</epage><pages>344-355</pages><issn>1025-6016</issn><eissn>1477-2639</eissn><abstract>Childhood malnutrition is highly prevalent and associated with high mortality risk. 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| identifier | ISSN: 1025-6016 |
| ispartof | Isotopes in environmental and health studies, 2017-08, Vol.53 (4), p.344-355 |
| issn | 1025-6016 1477-2639 |
| language | eng |
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| source | Taylor and Francis Science and Technology Collection |
| subjects | Acute Disease Adipose Tissue - metabolism Balancing Body Composition Body Water - metabolism Children Deuterium deuterium dilution Deuterium Oxide - administration & dosage Deuterium Oxide - pharmacokinetics Dilution equilibration time Feasibility studies Humans Infant Infants Intervention Malnutrition Malnutrition - diagnosis Pilot Projects Radioisotope Dilution Technique Saliva Saliva - metabolism saliva sampling Severity of Illness Index Spectroscopy, Fourier Transform Infrared Studies tracer technique |
| title | Deuterium dilution technique for body composition assessment: resolving methodological issues in children with moderate acute malnutrition |
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