Loading…
Autistic traits and components of the folate metabolic system: an explorative analysis in the eastern Indian ASD subjects
Objectives: Proper metabolism of the folate is crucial for maintaining DNA integrity, chromosome structure, methylation, as well as gene expression, and thus, folate is speculated to contribute to the etiology of different disorders. Since the etiology of autism spectrum disorder (ASD) is believed t...
Saved in:
Published in: | Nutritional neuroscience 2020-11, Vol.23 (11), p.860-867 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c366t-2971eb335ea294bc44ebd5962bb8b9048b66d7934baf4e19a90302bf5bb08f763 |
---|---|
cites | cdi_FETCH-LOGICAL-c366t-2971eb335ea294bc44ebd5962bb8b9048b66d7934baf4e19a90302bf5bb08f763 |
container_end_page | 867 |
container_issue | 11 |
container_start_page | 860 |
container_title | Nutritional neuroscience |
container_volume | 23 |
creator | Saha, Sharmistha Saha, Tanusree Sinha, Swagata Rajamma, Usha Mukhopadhyay, Kanchan |
description | Objectives: Proper metabolism of the folate is crucial for maintaining DNA integrity, chromosome structure, methylation, as well as gene expression, and thus, folate is speculated to contribute to the etiology of different disorders. Since the etiology of autism spectrum disorder (ASD) is believed to be influenced by both genetic and environmental factors, we hypothesized that functional single nucleotide polymorphisms (SNPs) affecting folate metabolic pathway may have a causal role in the etiology of ASD.
Methods: We analyzed three SNPs, rs2071010, rs2298444 and rs1801198 (in the folate receptor 1, folate receptor 2 and transcobalamin 2, respectively), in 867 ethnically matched subjects including 206 ASD probands and 286 controls. Plasma vitamin B
6
and folate were measured in age-matched probands and controls.
Results: ASD probands showed a higher frequency of rs2298444 'A' allele (P = 0.01) and genotypes with 'A' allele (P = 0.03) when compared with the controls. rs1801198 'C' allele and 'CG' genotype also showed higher occurrence in the probands (P = 0.009 and 0.005, respectively). Gender-based stratified analysis revealed a significant higher frequency of rs2298444 'A' allele (P = 0.003), genotypes with rs2298444 'A' allele (P = 0.003) and rs1801198 CG (P = 0.001) in the male probands. Studied variants also showed statistically significant associations with ASD-associated traits measured by the Childhood Autism Rating Scale. ASD subjects exhibited gross deficiency in vitamin B
6
level when compared with age-matched controls (P |
doi_str_mv | 10.1080/1028415X.2019.1570442 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_1028415X_2019_1570442</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179503205</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-2971eb335ea294bc44ebd5962bb8b9048b66d7934baf4e19a90302bf5bb08f763</originalsourceid><addsrcrecordid>eNp9kE2LFDEQhoMo7rr6E5QcvfSY7-54cli_FhY8qOAtJN0VzNKdjEla7X9vxpn16Knqheetggeh55TsKBnIK0rYIKj8tmOE6h2VPRGCPUCXVPSqGziRD9vemO4IXaAnpdwRwqgc1GN0wYnqFRv4Jdr2aw2lhhHXbEMt2MYJj2k5pAixxeRx_Q7Yp9lWwAtU69Lc6LKVCsvrhmP4fZhTtjX8hBbtvJVQcIh_e2AbliO-iVNo6P7zW1xWdwdjLU_RI2_nAs_O8wp9ff_uy_XH7vbTh5vr_W03cqVqx3RPwXEuwTIt3CgEuElqxZwbnCZicEpNvebCWS-AaqsJJ8x56RwZfK_4FXp5unvI6ccKpZollBHm2UZIazGM9loSzohsqDyhY06lZPDmkMNi82YoMUfr5t66OVo3Z-ut9-L8YnULTP9a95ob8OYEhOhTXuyvlOfJVLs1cT7bOIZi-P9__AHXLpMO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2179503205</pqid></control><display><type>article</type><title>Autistic traits and components of the folate metabolic system: an explorative analysis in the eastern Indian ASD subjects</title><source>EBSCOhost SPORTDiscus with Full Text</source><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Saha, Sharmistha ; Saha, Tanusree ; Sinha, Swagata ; Rajamma, Usha ; Mukhopadhyay, Kanchan</creator><creatorcontrib>Saha, Sharmistha ; Saha, Tanusree ; Sinha, Swagata ; Rajamma, Usha ; Mukhopadhyay, Kanchan</creatorcontrib><description>Objectives: Proper metabolism of the folate is crucial for maintaining DNA integrity, chromosome structure, methylation, as well as gene expression, and thus, folate is speculated to contribute to the etiology of different disorders. Since the etiology of autism spectrum disorder (ASD) is believed to be influenced by both genetic and environmental factors, we hypothesized that functional single nucleotide polymorphisms (SNPs) affecting folate metabolic pathway may have a causal role in the etiology of ASD.
Methods: We analyzed three SNPs, rs2071010, rs2298444 and rs1801198 (in the folate receptor 1, folate receptor 2 and transcobalamin 2, respectively), in 867 ethnically matched subjects including 206 ASD probands and 286 controls. Plasma vitamin B
6
and folate were measured in age-matched probands and controls.
Results: ASD probands showed a higher frequency of rs2298444 'A' allele (P = 0.01) and genotypes with 'A' allele (P = 0.03) when compared with the controls. rs1801198 'C' allele and 'CG' genotype also showed higher occurrence in the probands (P = 0.009 and 0.005, respectively). Gender-based stratified analysis revealed a significant higher frequency of rs2298444 'A' allele (P = 0.003), genotypes with rs2298444 'A' allele (P = 0.003) and rs1801198 CG (P = 0.001) in the male probands. Studied variants also showed statistically significant associations with ASD-associated traits measured by the Childhood Autism Rating Scale. ASD subjects exhibited gross deficiency in vitamin B
6
level when compared with age-matched controls (P < 0.001), which correlated with risk genetic variants.
Discussion: We infer from this pioneering study on eastern Indian subjects that vitamin B
6
deficiency, along with risk gene variants, may affect ASD-associated symptoms, warranting further investigation in large cohorts.</description><identifier>ISSN: 1028-415X</identifier><identifier>EISSN: 1476-8305</identifier><identifier>DOI: 10.1080/1028415X.2019.1570442</identifier><identifier>PMID: 30676283</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>ASD ; CARS score ; folate ; folate receptors ; rs2298444 ; transcobalamin ; vitamin B</subject><ispartof>Nutritional neuroscience, 2020-11, Vol.23 (11), p.860-867</ispartof><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-2971eb335ea294bc44ebd5962bb8b9048b66d7934baf4e19a90302bf5bb08f763</citedby><cites>FETCH-LOGICAL-c366t-2971eb335ea294bc44ebd5962bb8b9048b66d7934baf4e19a90302bf5bb08f763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30676283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saha, Sharmistha</creatorcontrib><creatorcontrib>Saha, Tanusree</creatorcontrib><creatorcontrib>Sinha, Swagata</creatorcontrib><creatorcontrib>Rajamma, Usha</creatorcontrib><creatorcontrib>Mukhopadhyay, Kanchan</creatorcontrib><title>Autistic traits and components of the folate metabolic system: an explorative analysis in the eastern Indian ASD subjects</title><title>Nutritional neuroscience</title><addtitle>Nutr Neurosci</addtitle><description>Objectives: Proper metabolism of the folate is crucial for maintaining DNA integrity, chromosome structure, methylation, as well as gene expression, and thus, folate is speculated to contribute to the etiology of different disorders. Since the etiology of autism spectrum disorder (ASD) is believed to be influenced by both genetic and environmental factors, we hypothesized that functional single nucleotide polymorphisms (SNPs) affecting folate metabolic pathway may have a causal role in the etiology of ASD.
Methods: We analyzed three SNPs, rs2071010, rs2298444 and rs1801198 (in the folate receptor 1, folate receptor 2 and transcobalamin 2, respectively), in 867 ethnically matched subjects including 206 ASD probands and 286 controls. Plasma vitamin B
6
and folate were measured in age-matched probands and controls.
Results: ASD probands showed a higher frequency of rs2298444 'A' allele (P = 0.01) and genotypes with 'A' allele (P = 0.03) when compared with the controls. rs1801198 'C' allele and 'CG' genotype also showed higher occurrence in the probands (P = 0.009 and 0.005, respectively). Gender-based stratified analysis revealed a significant higher frequency of rs2298444 'A' allele (P = 0.003), genotypes with rs2298444 'A' allele (P = 0.003) and rs1801198 CG (P = 0.001) in the male probands. Studied variants also showed statistically significant associations with ASD-associated traits measured by the Childhood Autism Rating Scale. ASD subjects exhibited gross deficiency in vitamin B
6
level when compared with age-matched controls (P < 0.001), which correlated with risk genetic variants.
Discussion: We infer from this pioneering study on eastern Indian subjects that vitamin B
6
deficiency, along with risk gene variants, may affect ASD-associated symptoms, warranting further investigation in large cohorts.</description><subject>ASD</subject><subject>CARS score</subject><subject>folate</subject><subject>folate receptors</subject><subject>rs2298444</subject><subject>transcobalamin</subject><subject>vitamin B</subject><issn>1028-415X</issn><issn>1476-8305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE2LFDEQhoMo7rr6E5QcvfSY7-54cli_FhY8qOAtJN0VzNKdjEla7X9vxpn16Knqheetggeh55TsKBnIK0rYIKj8tmOE6h2VPRGCPUCXVPSqGziRD9vemO4IXaAnpdwRwqgc1GN0wYnqFRv4Jdr2aw2lhhHXbEMt2MYJj2k5pAixxeRx_Q7Yp9lWwAtU69Lc6LKVCsvrhmP4fZhTtjX8hBbtvJVQcIh_e2AbliO-iVNo6P7zW1xWdwdjLU_RI2_nAs_O8wp9ff_uy_XH7vbTh5vr_W03cqVqx3RPwXEuwTIt3CgEuElqxZwbnCZicEpNvebCWS-AaqsJJ8x56RwZfK_4FXp5unvI6ccKpZollBHm2UZIazGM9loSzohsqDyhY06lZPDmkMNi82YoMUfr5t66OVo3Z-ut9-L8YnULTP9a95ob8OYEhOhTXuyvlOfJVLs1cT7bOIZi-P9__AHXLpMO</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Saha, Sharmistha</creator><creator>Saha, Tanusree</creator><creator>Sinha, Swagata</creator><creator>Rajamma, Usha</creator><creator>Mukhopadhyay, Kanchan</creator><general>Taylor & Francis</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201101</creationdate><title>Autistic traits and components of the folate metabolic system: an explorative analysis in the eastern Indian ASD subjects</title><author>Saha, Sharmistha ; Saha, Tanusree ; Sinha, Swagata ; Rajamma, Usha ; Mukhopadhyay, Kanchan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-2971eb335ea294bc44ebd5962bb8b9048b66d7934baf4e19a90302bf5bb08f763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ASD</topic><topic>CARS score</topic><topic>folate</topic><topic>folate receptors</topic><topic>rs2298444</topic><topic>transcobalamin</topic><topic>vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saha, Sharmistha</creatorcontrib><creatorcontrib>Saha, Tanusree</creatorcontrib><creatorcontrib>Sinha, Swagata</creatorcontrib><creatorcontrib>Rajamma, Usha</creatorcontrib><creatorcontrib>Mukhopadhyay, Kanchan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutritional neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saha, Sharmistha</au><au>Saha, Tanusree</au><au>Sinha, Swagata</au><au>Rajamma, Usha</au><au>Mukhopadhyay, Kanchan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autistic traits and components of the folate metabolic system: an explorative analysis in the eastern Indian ASD subjects</atitle><jtitle>Nutritional neuroscience</jtitle><addtitle>Nutr Neurosci</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>23</volume><issue>11</issue><spage>860</spage><epage>867</epage><pages>860-867</pages><issn>1028-415X</issn><eissn>1476-8305</eissn><abstract>Objectives: Proper metabolism of the folate is crucial for maintaining DNA integrity, chromosome structure, methylation, as well as gene expression, and thus, folate is speculated to contribute to the etiology of different disorders. Since the etiology of autism spectrum disorder (ASD) is believed to be influenced by both genetic and environmental factors, we hypothesized that functional single nucleotide polymorphisms (SNPs) affecting folate metabolic pathway may have a causal role in the etiology of ASD.
Methods: We analyzed three SNPs, rs2071010, rs2298444 and rs1801198 (in the folate receptor 1, folate receptor 2 and transcobalamin 2, respectively), in 867 ethnically matched subjects including 206 ASD probands and 286 controls. Plasma vitamin B
6
and folate were measured in age-matched probands and controls.
Results: ASD probands showed a higher frequency of rs2298444 'A' allele (P = 0.01) and genotypes with 'A' allele (P = 0.03) when compared with the controls. rs1801198 'C' allele and 'CG' genotype also showed higher occurrence in the probands (P = 0.009 and 0.005, respectively). Gender-based stratified analysis revealed a significant higher frequency of rs2298444 'A' allele (P = 0.003), genotypes with rs2298444 'A' allele (P = 0.003) and rs1801198 CG (P = 0.001) in the male probands. Studied variants also showed statistically significant associations with ASD-associated traits measured by the Childhood Autism Rating Scale. ASD subjects exhibited gross deficiency in vitamin B
6
level when compared with age-matched controls (P < 0.001), which correlated with risk genetic variants.
Discussion: We infer from this pioneering study on eastern Indian subjects that vitamin B
6
deficiency, along with risk gene variants, may affect ASD-associated symptoms, warranting further investigation in large cohorts.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>30676283</pmid><doi>10.1080/1028415X.2019.1570442</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1028-415X |
ispartof | Nutritional neuroscience, 2020-11, Vol.23 (11), p.860-867 |
issn | 1028-415X 1476-8305 |
language | eng |
recordid | cdi_crossref_primary_10_1080_1028415X_2019_1570442 |
source | EBSCOhost SPORTDiscus with Full Text; Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
subjects | ASD CARS score folate folate receptors rs2298444 transcobalamin vitamin B |
title | Autistic traits and components of the folate metabolic system: an explorative analysis in the eastern Indian ASD subjects |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A59%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Autistic%20traits%20and%20components%20of%20the%20folate%20metabolic%20system:%20an%20explorative%20analysis%20in%20the%20eastern%20Indian%20ASD%20subjects&rft.jtitle=Nutritional%20neuroscience&rft.au=Saha,%20Sharmistha&rft.date=2020-11-01&rft.volume=23&rft.issue=11&rft.spage=860&rft.epage=867&rft.pages=860-867&rft.issn=1028-415X&rft.eissn=1476-8305&rft_id=info:doi/10.1080/1028415X.2019.1570442&rft_dat=%3Cproquest_cross%3E2179503205%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c366t-2971eb335ea294bc44ebd5962bb8b9048b66d7934baf4e19a90302bf5bb08f763%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2179503205&rft_id=info:pmid/30676283&rfr_iscdi=true |