In vitro antimicrobial activity of honokiol against Staphylococcus aureus in biofilm mode

Staphylococcus aureus (S. aureus) can attach to food, host tissues and the surfaces of medical implants and form a biofilm, which makes it difficult to eliminate. The purpose of this study was to evaluate the effect of honokiol on biofilm-grown S. aureus. In this report, honokiol showed effective an...

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Bibliographic Details
Published in:Journal of asian natural products research 2016-12, Vol.18 (12), p.1178-1185
Main Authors: Li, Wen-Li, Zhao, Xing-Chen, Zhao, Zi-Wen, Huang, Yan-Jun, Zhu, Xuan-Zhi, Meng, Ri-Zeng, Shi, Ce, Yu, Lu, Guo, Na
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
biofilm
Biofilms
Biofilms - drug effects
Biphenyl Compounds - analysis
Biphenyl Compounds - chemistry
Biphenyl Compounds - pharmacology
DNA - analysis
eDNA
Gram-positive bacteria
honokiol
Lignans - analysis
Lignans - chemistry
Lignans - pharmacology
Molecular Structure
Pathogens
PIA
Staphylococcus aureus
Staphylococcus aureus - drug effects
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Summary:Staphylococcus aureus (S. aureus) can attach to food, host tissues and the surfaces of medical implants and form a biofilm, which makes it difficult to eliminate. The purpose of this study was to evaluate the effect of honokiol on biofilm-grown S. aureus. In this report, honokiol showed effective antibacterial activity against S. aureus in biofilms. S. aureus isolates are capable of producing distinct types of biofilms mediated by polysaccharide intercellular adhesion (PIA) or extracellular DNA (eDNA). The biofilms' susceptibility to honokiol was evaluated using confocal laser scanning microscopy (CLSM) analysis. The transcript levels of the biofilm-related genes, the expression of PIA, and the amount of eDNA of biofilm-grown S. aureus exposed to honokiol were also investigated. The results of this study show that honokiol can detach existing biofilms, kill bacteria in biofilms, and simultaneously inhibit the transcript levels of sarA, cidA and icaA, eDNA release, and the expression of PIA.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2016.1194829